EPS8L2

EPS8-like 2

PDB rendering based on 1wwu.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1WWU, 1WXB

Identifiers

Symbols

EPS8L2 ; EPS8R2

External IDs

OMIM: 614988 MGI: 2138828 HomoloGene: 69358 GeneCards: EPS8L2 Gene

Gene ontology
Molecular function	• actin binding • Rho guanyl-nucleotide exchange factor activity • Rac guanyl-nucleotide exchange factor activity
Cellular component	• cytoplasm • plasma membrane • vesicle • ruffle membrane • protein complex • extracellular exosome
Biological process	• Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of GTPase activity • positive regulation of ruffle assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
0.69 – 0.73 Mb

Chr 7:
141.34 – 141.36 Mb

PubMed search

Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene.^[1]^[2]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown.^[2]

References

↑ Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
1 2 "Entrez Gene: EPS8L2 EPS8-like 2".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Offenhäuser N, Borgonovo A, Disanza A; et al. (2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.". Mol. Biol. Cell 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W; et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.

PDB gallery

1wwu: Solution structure of the SAM_PNT domain of human protein FLJ21935

1wxb: Solution structure of the SH3 domain from human epidermal growth factor receptor pathway substrate 8-like protein

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EPS8L2

References

Further reading