EPHA8

EPH receptor A8

PDB rendering based on 1ucv.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1UCV, 1X5L, 3KUL

Identifiers

Symbols

EPHA8 ; EEK; EK3; HEK3

External IDs

OMIM: 176945 MGI: 109378 HomoloGene: 22436 ChEMBL: 4134 GeneCards: EPHA8 Gene

EC number

2.7.10.1

Gene ontology
Molecular function	• GPI-linked ephrin receptor activity • ATP binding
Cellular component	• plasma membrane • integral component of plasma membrane • early endosome membrane • neuron projection
Biological process	• substrate-dependent cell migration • cell adhesion • axon guidance • neuron remodeling • peptidyl-tyrosine phosphorylation • regulation of cell adhesion • neuron projection development • regulation of cell adhesion mediated by integrin • positive regulation of MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • protein autophosphorylation • ephrin receptor signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
22.56 – 22.6 Mb

Chr 4:
136.93 – 136.96 Mb

PubMed search

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.^[1]^[2]

Function

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.^[2]

Interactions

EPHA8 has been shown to interact with FYN.^[3]

References

↑ Chan J, Watt VM (Aug 1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene 6 (6): 1057–61. PMID 1648701.
1 2 "Entrez Gene: EPHA8 EPH receptor A8".
↑ Choi S, Park S (Sep 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895.

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Holland SJ, Peles E, Pawson T, Schlessinger J (1998). "Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta.". Curr. Opin. Neurobiol. 8 (1): 117–27. doi:10.1016/S0959-4388(98)80015-9. PMID 9568399.
Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
Nakamoto T, Kain KH, Ginsberg MH (2004). "Neurobiology: New connections between integrins and axon guidance.". Curr. Biol. 14 (3): R121–3. doi:10.1016/j.cub.2004.01.020. PMID 14986683.
Yamaguchi Y, Pasquale EB (2004). "Eph receptors in the adult brain.". Curr. Opin. Neurobiol. 14 (3): 288–96. doi:10.1016/j.conb.2004.04.003. PMID 15194108.
Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function.". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 10 (4): 304–14. doi:10.1177/1073858403262221. PMID 15271258.
Park S, Sánchez MP (1997). "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands.". Oncogene 14 (5): 533–42. doi:10.1038/sj.onc.1200857. PMID 9053851.
Park S, Frisén J, Barbacid M (1997). "Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors.". EMBO J. 16 (11): 3106–14. doi:10.1093/emboj/16.11.3106. PMC 1169929. PMID 9214628.
Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
Lemke G (1998). "A coherent nomenclature for Eph receptors and their ligands.". Mol. Cell. Neurosci. 9 (5–6): 331–2. doi:10.1006/mcne.1997.0630. PMID 9361271.
Choi S, Park S (1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.". Oncogene 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895.

PDB gallery

1ucv: Sterile alpha motif (SAM) domain of ephrin type-A receptor 8

1x5l: Solution structure of the second fn3 domain of Eph receptor A8 protein

Protein kinases: tyrosine kinases (EC 2.7.10)

Receptor tyrosine kinases (EC 2.7.10.1)

Growth factor receptors

EGF receptor family	EGFR ERBB2 ERBB3 ERBB4

Insulin receptor family	IGF1R INSR INSRR

PDGF receptor family	CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB)

FGF receptor family	FGFR1 FGFR2 FGFR3 FGFR4

VEGF receptors family	VEGFR1 VEGFR2 VEGFR3

HGF receptor family	MET RON

Trk receptor family	NTRK1 NTRK2 NTRK3

EPH receptor family

LTK receptor family

TIE receptor family

ROR receptor family

ROR1
ROR2

DDR receptor family

DDR1
DDR2

PTK7 receptor family

PTK7

RYK receptor family

MuSK receptor family

MUSK

ROS receptor family

ROS1

AATYK receptor family

AATYK
AATYK2

AXL receptor family

RET receptor family

uncatagorised

STYK1

Non-receptor tyrosine kinases (EC 2.7.10.2)

ABL family	ABL1 ARG

ACK family	ACK1 TNK1

CSK family	CSK MATK

FAK family	FAK PYK2

FES family	FES FER

FRK family	FRK BRK SRMS

JAK family	JAK1 JAK2 JAK3 TYK2

SRC-A family	SRC FGR FYN YES1

SRC-B family	BLK HCK LCK LYN

TEC family	TEC BMX BTK ITK TXK

SYK family	SYK ZAP70

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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EPHA8

Function

Interactions

References

Further reading