ELP3

Elongator acetyltransferase complex subunit 3

Identifiers

ELP3 ; KAT9

External IDs

OMIM: 612722 MGI: 1921445 HomoloGene: 7105 IUPHAR: 2653 GeneCards: ELP3 Gene

2.3.1.48

Gene ontology
Molecular function	• RNA polymerase II core binding • protein binding • phosphorylase kinase regulator activity • H3 histone acetyltransferase activity • H4 histone acetyltransferase activity • metal ion binding • iron-sulfur cluster binding
Cellular component	• histone acetyltransferase complex • nucleolus • cytoplasm • transcription elongation factor complex • Elongator holoenzyme complex
Biological process	• neuron migration • tRNA wobble uridine modification • chromatin organization • regulation of transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • central nervous system development • positive regulation of cell migration • histone H3 acetylation • histone H4 acetylation • regulation of protein kinase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
28.09 – 28.19 Mb

Chr 14:
65.53 – 65.59 Mb

PubMed search

Elongator complex protein 3 is a protein that in humans is encoded by the ELP3 gene.^[1]^[2]

References

↑ Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725.
↑ "Entrez Gene: ELP3 elongation protein 3 homolog (S. cerevisiae)".

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Han Q, Hou X, Su D; et al. (2007). "hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells.". Acta Biochim. Biophys. Sin. (Shanghai) 39 (6): 453–61. doi:10.1111/j.1745-7270.2007.00293.x. PMID 17558451.

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ELP3

References

Further reading