EIF5

Eukaryotic translation initiation factor 5

PDB rendering based on 2g2k.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2E9H, 2G2K, 2IU1

Identifiers

Symbols

EIF5 ; EIF-5; EIF-5A

External IDs

OMIM: 601710 MGI: 95309 HomoloGene: 49610 GeneCards: EIF5 Gene

Gene ontology
Molecular function	• translation initiation factor activity • GTPase activity • protein binding • GTP binding • translation factor activity, RNA binding • poly(A) RNA binding
Cellular component	• nucleus • cytoplasm • cytosol • plasma membrane
Biological process	• translation • translational initiation • regulation of translational initiation • gene expression • cellular protein metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
103.33 – 103.35 Mb

Chr 12:
111.54 – 111.55 Mb

PubMed search

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.^[1]^[2]

EIF5 is a GTPase-activating protein.^[3]

References

↑ Si K, Das K, Maitra U (Aug 1996). "Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5)". J Biol Chem 271 (28): 16934–8. doi:10.1074/jbc.271.28.16934. PMID 8663286.
↑ "Entrez Gene: EIF5 eukaryotic translation initiation factor 5".
↑ Das S, Ghosh R, Maitra U (March 2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein". J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200. PMID 11092890.

External links

Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors

Das S, Maiti T, Das K, Maitra U (1998). "Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2.". J. Biol. Chem. 272 (50): 31712–8. doi:10.1074/jbc.272.50.31712. PMID 9395514.
Bandyopadhyay A, Maitra U (1999). "Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells.". Nucleic Acids Res. 27 (5): 1331–7. doi:10.1093/nar/27.5.1331. PMC 148320. PMID 9973622.
Das S, Maitra U (2000). "Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo.". Mol. Cell. Biol. 20 (11): 3942–50. doi:10.1128/MCB.20.11.3942-3950.2000. PMC 85746. PMID 10805737.
Choi SK, Olsen DS, Roll-Mecak A; et al. (2000). "Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2.". Mol. Cell. Biol. 20 (19): 7183–91. doi:10.1128/MCB.20.19.7183-7191.2000. PMC 86272. PMID 10982835.
Das S, Ghosh R, Maitra U (2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.". J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200. PMID 11092890.
Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Asano K, Shalev A, Phan L; et al. (2001). "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.". EMBO J. 20 (9): 2326–37. doi:10.1093/emboj/20.9.2326. PMC 125443. PMID 11331597.
Majumdar R, Bandyopadhyay A, Deng H, Maitra U (2002). "Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo.". Nucleic Acids Res. 30 (5): 1154–62. doi:10.1093/nar/30.5.1154. PMC 101238. PMID 11861906.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. doi:10.1073/pnas.0437845100. PMC 149867. PMID 12569173.
Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Homma MK, Wada I, Suzuki T; et al. (2005). "CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression.". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15688–93. doi:10.1073/pnas.0506791102. PMC 1266118. PMID 16227438.
Conte MR, Kelly G, Babon J; et al. (2006). "Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors.". Biochemistry 45 (14): 4550–8. doi:10.1021/bi052387u. PMID 16584190.
Bieniossek C, Schütz P, Bumann M; et al. (2006). "The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5.". J. Mol. Biol. 360 (2): 457–65. doi:10.1016/j.jmb.2006.05.021. PMID 16781736.
Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

2g2k: NMR structure of an N-terminal fragment of the eukaryotic initiation factor 5 (eIF5)

2iu1: CRYSTAL STRUCTURE OF EIF5 C-TERMINAL DOMAIN

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Ribosomal proteins

Initiation factor

Prokaryotic

Archaeal

aIF1
aIF2
aIF5
aIF6

Eukaryotic

eIF1	EIF1AX AY 1B

eIF2	EIF2S1 EIF2S2 EIF2S3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF-2 kinase

eIF3	EIF3A B C D F G H I J K M S6

eIF4	EIF4A2 A3 B E1 E2 G1 G2 G3 H

eIF5	EIF5A A2 B

eIF6	EIF6

Elongation factor

Prokaryotic	EF-Tu EF-Ts EF-G

Archaeal	aEF-1, aEF-2

Eukaryotic	EEF-1 EEF1A1 EEF1A2 EEF1A3 EEF1B1 EEF1B2 EEF1B3 EEF1B4 EEF1D EEF1E1 EEF1G EEF2

Release factor

Other

Other concepts

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EIF5

References

External links

Further reading