EIF2C2

Argonaute RISC catalytic component 2

Rendering based on PDB 3LUC.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3LUC, 3LUD, 3LUG, 3LUH, 3LUJ, 3LUK, 3QX8, 3QX9, 4F3T, 4OLA, 4OLB, 4W5N, 4W5O, 4W5Q, 4W5R, 4W5T

Identifiers

Symbols

AGO2 ; EIF2C2; Q10

External IDs

OMIM: 606229 MGI: 2446632 HomoloGene: 81825 GeneCards: AGO2 Gene

EC number

3.1.26.n2

Gene ontology
Molecular function	• RNA 7-methylguanosine cap binding • RNA polymerase II core binding • core promoter binding • double-stranded RNA binding • single-stranded RNA binding • mRNA binding • translation initiation factor activity • endoribonuclease activity • protein binding • protein C-terminus binding • siRNA binding • miRNA binding • poly(A) RNA binding • metal ion binding • endoribonuclease activity, cleaving siRNA-paired mRNA • pre-miRNA binding • endoribonuclease activity, cleaving miRNA-paired mRNA
Cellular component	• cytoplasmic mRNA processing body • nucleus • nucleoplasm • cytoplasm • cytosol • polysome • mRNA cap binding complex • membrane • RISC complex • dendrite • ribonucleoprotein complex • micro-ribonucleoprotein complex • RISC-loading complex
Biological process	• transcription, DNA-templated • translation • translational initiation • epidermal growth factor receptor signaling pathway • Notch signaling pathway • fibroblast growth factor receptor signaling pathway • post-embryonic development • gene expression • RNA secondary structure unwinding • miRNA metabolic process • posttranscriptional gene silencing • gene silencing by RNA • pre-miRNA processing • siRNA loading onto RISC involved in RNA interference • production of miRNAs involved in gene silencing by miRNA • negative regulation of translation involved in gene silencing by miRNA • mRNA cleavage involved in gene silencing by miRNA • miRNA loading onto RISC involved in gene silencing by miRNA • Fc-epsilon receptor signaling pathway • innate immune response • positive regulation of transcription from RNA polymerase II promoter • negative regulation of translational initiation • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • RNA phosphodiester bond hydrolysis, endonucleolytic • mRNA cleavage involved in gene silencing by siRNA • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
140.52 – 140.64 Mb

Chr 15:
73.1 – 73.18 Mb

PubMed search

Protein argonaute-2 is a protein that in humans is encoded by the EIF2C2 gene.^[1]^[2]^[3]

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.^[3]

Interactions

EIF2C2 has been shown to interact with

References

↑ Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J (Dec 1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression". Genomics 61 (2): 210–8. doi:10.1006/geno.1999.5951. PMID 10534406.
↑ Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.
1 2 "Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2".
↑ Nelson PT, Hatzigeorgiou AG, Mourelatos Z (March 2004). "miRNP:mRNA association in polyribosomes in a human neuronal cell line". RNA 10 (3): 387–94. doi:10.1261/rna.5181104. PMC 1370934. PMID 14970384.
1 2 Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.
↑ Doi N, Zenno S, Ueda R, Ohki-Hamazaki H, Ui-Tei K, Saigo K (January 2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors". Curr. Biol. 13 (1): 41–6. doi:10.1016/S0960-9822(02)01394-5. PMID 12526743.
↑ Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST (February 2004). "Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway". Nat. Neurosci. 7 (2): 113–7. doi:10.1038/nn1174. PMID 14703574.
↑ Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150.

EIF2C2

Interactions

References

Further reading