Purified water

Bottle for distilled water in the Farmacia Real in Madrid

Purified water is water that has been mechanically filtered or processed to remove impurities and make it suitable for use. Distilled water has been the most common form of purified water, but, in recent years, water is more frequently purified by other processes including capacitive deionization, reverse osmosis, carbon filtering, microfiltration, ultrafiltration, ultraviolet oxidation, or electrodeionization. Combinations of a number of these processes have come into use to produce water of such high purity that its trace contaminants are measured in parts per billion (ppb) or parts per trillion (ppt). Purified water has many uses, largely in the production of medications, in science and engineering laboratories and industries, and is produced in a range of purities. It can be produced on site for immediate use or purchased in containers. Purified water in colloquial English can also refer to water which has been treated ("rendered potable") to neutralize, but not necessarily remove contaminants considered harmful to humans or animals.

Parameters of water purity

Purified water is usually produced by the purification of potable water (city water) or natural water. The impurities that may need to be removed are:

• inorganic ions (typically monitored as electrical conductivity or resistivity or specific tests)
• organic compounds (typically monitored as TOC or by specific tests)
• bacteria (monitored by total viable counts or epifluorescence)
• endotoxins and nucleases (monitored by LAL or specific enzyme tests)
• particulates (typically controlled by filtration)
• gases (typically managed by degassing when required)

Purification methods

Distillation

Distilled water is produced by a process of distillation and has an electrical conductivity of not more than 11 µS/cm and total dissolved solids of less than 10 mg/litre.^[1] Distillation involves boiling the water and then condensing the vapor into a clean container, leaving solid contaminants behind. Distillation produces very pure water. A white or yellowish mineral scale is left in the distillation apparatus, which requires regular cleaning. Distilled water, like all purified water, must be stored in a sterilized container to guarantee the absence of bacteria. For many procedures, more economical alternatives are available, such as deionized water, and are used in place of distilled water.

Double distillation

Double-distilled water (abbreviated "ddH₂O", "Bidest. water" or "DDW") is prepared by slow boiling the uncontaminated condensed water vapor from a prior slow boiling. Historically, it was the de facto standard for highly purified laboratory water for biochemistry and used in laboratory trace analysis until combination purification methods of water purification became widespread.

Deionization

Large cation/anion ion exchangers used in demineralization of boiler feedwater.^[2]

Deionized water (DI water, DIW or de-ionized water), often confused with demineralized water / DM water,^[3] is water that has had almost all of its mineral ions removed, such as cations like sodium, calcium, iron, and copper, and anions such as chloride and sulfate. Deionization is a chemical process that uses specially manufactured ion-exchange resins, which exchange hydrogen and hydroxide ions for dissolved minerals, and then recombine to form water. Because most non-particulate water impurities are dissolved salts, deionization produces a high purity water that is generally similar to distilled water, and this process is quick and without scale buildup. However, deionization does not significantly remove uncharged organic molecules, viruses or bacteria, except by incidental trapping in the resin. Specially made strong base anion resins can remove Gram-negative bacteria. Deionization can be done continuously and inexpensively using electrodeionization.

Three types of deionization exist: co-current, counter-current, and mixed bed.

Co-current deionization

Co-current deionization refers the original downflow process where both input water and regeneration chemicals enter at the top of an ion exchange column and exit at the bottom. Co-current operating costs are comparatively higher than counter-current deionization because of the additional usage of regenerants. Because regenerant chemicals are dilute when they encounter the bottom or finishing resins in an ion exchange column, the product quality is lower than a similarly sized counter-flow column.

The process is still used, and can be maximized with the fine tuning of the flow of regenerants within the ion exchange column.

Counter-current deionization

Counter-current deionization comes in two forms, each requiring engineered internals:

1. Upflow columns where input water enters from the bottom and regenerants enter from the top of the ion exchange column.
2. Upflow regeneration where water enters from the top and regenerants enter from the bottom.

In both cases, separate distribution headers (input water, input regenerant, exit water, and exit regenerant) must be tuned to: the input water quality and flow, the time of operation between regenerations, and the desired product water analysis.

Counter-current deionization is the more attractive method of ion exchange. Chemicals (regenerants) flow in the opposite direction to the service flow. Less time for regeneration is required when compared to concurrent columns. The quality of the finished product can be as low as .5 parts per million. The main advantage of counter-current deionization is the low operating cost, due to a low usage of regenerants during the regeneration process.

Mixed bed deionization

Mixed bed deionization is a 50/50 mixture of cation and anion resin combined in a single ion exchange column. With proper pretreatment, product water purified from a single pass through a mixed bed ion exchange column is the purest that can be made. Most commonly, mixed bed demineralizers are used for final water polishing to clean the last few ions within water prior to use. Small mixed bed deionization units have no regeneration capability. Commercial mixed bed deionization units have elaborate internal water and regenerant distribution systems for regeneration. A control system operates pumps and valves for the regenerants of spent anions and cations resins within the ion exchange column. Each is regenerated separately, then remixed during the regeneration process. Because of the high quality of product water achieved, and because of the expense and difficulty of regeneration, mixed bed demineralizers are used only when the highest purity water is required.

Demineralization

Demineralization is often a term used interchangeably with deionization. Demineralization is essentially removing all the minerals that can be found in natural water. This process is usually done when the water will be used for chemical processes and the minerals present may interfere with the other chemicals. All chemistic and beauty products have to be made with demineralized water for this reason. With the demineralization process, the water is "softened" replacing the undesired minerals with different salts (NaCl). Demineralized water has a higher conductivity than deionised water.

Other processes

Other processes are also used to purify water, including reverse osmosis, carbon filtration, microporous filtration, ultrafiltration, ultraviolet oxidation, or electrodialysis. These are used in place of, or in addition to, the processes listed above. Processes rendering water potable but not necessarily closer to being pure H₂O / hydroxide + hydronium ions include the use of dilute sodium hypochlorite, ozone, mixed-oxidants (electro-catalyzed H₂O + NaCl), and iodine; See discussion regarding potable water treatments under "Health effects" below.

Uses

Purified water is suitable for many applications, including autoclaves, hand-pieces, laboratory testing, laser cutting, and automotive use.^[4] Purification removes contaminants that may interfere with processes, or leave residues on evaporation. Although water is generally considered to be a good electrical conductor—for example domestic electrical systems are considered particularly hazardous to people if they may be in contact with wet surfaces—pure water is a poor conductor. The conductivity of sea-water is typically 5 S/m,^[5] drinking water is typically in the range of 5-50 mS/m, while highly purified water can be as low as 5.5 μS/m (0.055 µS/cm), a ratio of about 1,000,000:1,000:1.

Purified water is also used in the pharmaceutical industry. Water of this grade is widely used as a raw material, ingredient, and solvent in the processing, formulation, and manufacture of pharmaceutical products, active pharmaceutical ingredients (APIs) and intermediates, compendial articles, and analytical reagents. The microbiological content of the water is of importance and the water must be regularly monitored and tested to show that it remains within microbiological control.^[6]

Laboratory use

Technical standards on water quality have been established by a number of professional organizations, including the American Chemical Society (ACS), ASTM International, the U.S. National Committee for Clinical Laboratory Standards (NCCLS) which is now CLSI, and the U.S. Pharmacopeia (USP). The ASTM, NCCLS, and ISO 3696 or the International Organization for Standardization classify purified water into Grade 1–3 or Types I–IV depending on the level of purity. These organizations have similar, although not identical, parameters for highly purified water.

Note that the European Pharmacopeia uses Highly Purified Water (HPW) as a definition for water meeting the quality of Water For Injection, without however having undergone distillation. In the laboratory context, highly purified water is used to denominate various qualities of water having been "highly" purified.

Regardless of which organization's water quality norm is used, even Type I water may require further purification depending on the specific laboratory application. For example, water that is being used for molecular-biology experiments needs to be DNase or RNase-free, which requires special additional treatment or functional testing. Water for microbiology experiments needs to be completely sterile, which is usually accomplished by autoclaving. Water used to analyze trace metals may require the elimination of trace metals to a standard beyond that of the Type I water norm.

Criticism

A member of the ASTM D19 (Water) Committee, Erich L. Gibbs, criticized ASTM Standard D1193, by saying "Type I water could be almost anything – water that meets some or all of the limits, part or all of the time, at the same or different points in the production process."^[8]

Electrical conductivity

The electrical conductivity of ultra-pure water is 5.5 × 10⁻⁸ S/cm (18 MΩ·cm in the reciprocal terms of electrical resistivity) and is due only to H⁺ and OH⁻ ions produced in the water dissociation equilibrium.^[9][10] This low conductivity is only achieved, however, in the presence of dissolved monatomic gases. Completely de-gassed ultrapure water has a conductivity of 1.2 × 10⁻⁴ S/m, whereas on equilibration to the atmosphere it is 7.5 × 10⁻⁵ S/m due to dissolved CO₂ in it.^[9] The highest grades of ultrapure water should not be stored in glass or plastic containers because these container materials leach (release) contaminants at very low concentrations. Storage vessels made of silica are used for less-demanding applications and vessels of ultrapure tin are used for the highest-purity applications. It is worth noting that, although electrical conductivity only indicates the presence of ions, the majority of common contaminants found naturally in water ionize to some degree. This ionization is a good measure of the efficacy of a filtration system, and more expensive systems incorporate conductivity-based alarms to indicate when filters should be refreshed or replaced. For comparison,^[11] sea water has a conductivity of perhaps 5 S/m (53 mS/cm is quoted), while normal un-purified tap water may have conductivity of 5 mS/m (50 μS/cm) (to within an order of magnitude), which is still about 2 or 3 orders of magnitude higher than the output from a well-functioning demineralizing or distillation mechanism, so low levels of contamination or declining performance are easily detected.

Industrial uses

Some industrial processes, notably in the semiconductor and pharmaceutical industries, need large amounts of very pure water. In these situations, feedwater is first processed into purified water and then further processed to produce ultrapure water.

Other uses

Distilled or deionized water is commonly used to top up the lead-acid batteries used in cars and trucks and for other applications. The presence of foreign ions commonly found in tap water will drastically shorten the lifespan of a lead-acid battery.

Distilled or deionized water is preferable to tap water for use in automotive cooling systems.

Using deionised or distilled water in appliances that evaporate water, such as steam irons and humidifiers, can reduce the build-up of mineral scale, which shortens appliance life. Some appliance manufacturers say that deionised water is no longer necessary.^[12][13]

Purified water is used in freshwater and marine aquariums. Since it does not contain impurities such as copper and chlorine, it helps to keep fish free from diseases, and avoids the build-up of algae on aquarium plants due to its lack of phosphate and silicate. Deionized water should be re-mineralized before use in aquaria, since it lacks many macro- and micro-nutrients needed by plants and fish.

Water (sometimes mixed with methanol) has been used to extend the performance of aircraft engines. In piston engines, it acts to delay the onset of engine knocking. In turbine engines, it allows more fuel flow for a given turbine temperature limit, and increases mass flow. As an example, it was used on early Boeing 707 models.^[14] Advanced materials and engineering have since rendered such systems obsolete for new designs; however, spray-cooling of incoming air-charge is still used to a limited extent with off-road turbo-charged engines (road-race track cars).

Deionized water is very often used as an "ingredient" in many cosmetics and pharmaceuticals, where it is sometimes referred to as "aqua" on product ingredient labels; see International Nomenclature of Cosmetic Ingredients.

Because of its high relative dielectric constant (~80), deionized water is also used (for short durations, when the resistive losses are acceptable) as a high voltage dielectric in many pulsed power applications, such as the Sandia National Laboratories Z Machine.

Distilled water can be used in PC watercooling systems and Laser Marking Systems. The lack of impurity in the water means that the system stays clean and prevents a buildup of bacteria and algae. Also, the low conductance reduces the risk of electrical damage in the event of a leak.

When used as a rinse after washing cars, windows, and similar applications, purified water dries without leaving spots caused by dissolved solutes.

Deionized water is used in water-fog fire-extinguishing systems used in sensitive environments, such as where high-voltage electrical and sensitive electronic equipment is used. The 'sprinkler' nozzles use much finer spray jets than other systems, and operate at up 35 MPa (350 bar; 5,000 psi) of pressure. The extremely fine mist produced takes the heat out of a fire rapidly, and the fine droplets of water are nonconducting (when deionized) and are less likely to damage sensitive equipment. Deionized water, however, is inherently acidic and contaminants (such as copper, dust, stainless and carbon steel, and many other common materials) rapidly supply ions, thus re-ionizing the water. It is not generally considered acceptable to spray water on electrical circuits that are powered, and it is generally considered undesirable to use water in electrical contexts.^{[15][16][17][18]}

Distilled or purified water is used in humidors to prevent cigars from collecting bacteria, mold, and contaminants, as well as to prevent residue from forming on the humidifier material.

Window cleaners using water-fed pole systems also use purified water because it enables the windows to dry by themselves leaving no stains or smears. The use of purified water from water-fed poles also prevents the need for using ladders and therefore ensure compliance with Work at Height Legislation in the UK.

Health effects of drinking purified water

Distillation removes all minerals from water, and the membrane methods of reverse osmosis and nanofiltration remove most, or virtually all, minerals. This results in demineralized water, which has not been proven to be healthier than drinking water. The World Health Organization investigated the health effects of demineralized water in 1980, and its experiments in humans found that demineralized water increased diuresis and the elimination of electrolytes, with decreased serum potassium concentration. Magnesium, calcium and other nutrients in water can help to protect against nutritional deficiency. Recommendations for magnesium have been put at a minimum of 10 mg/L with 20–30 mg/L optimum; for calcium a 20 mg/L minimum and a 40–80 mg/L optimum, and a total water hardness (adding magnesium and calcium) of 2–4 mmol/L. At water hardness above 5 mmol/L, higher incidences of gallstones, kidney stones, urinary stones, arthrosis, and arthropathies have been observed. For fluoride, the concentration recommended for dental health is 0.5–1.0 mg/L, with a maximum guideline value of 1.5 mg/L to avoid dental fluorosis.^[19]

Water filtration devices are becoming increasingly common in households. Most of these devices do not distill water, though there continues to be an increase in consumer-oriented water distillers and reverse osmosis machines being sold and used. Municipal water supplies often add or have trace impurities at levels that are regulated to be safe for consumption. Much of these additional impurities, such as volatile organic compounds, fluoride, and an estimated 75,000+ other chemical compounds^[20][21][22] are not removed through conventional filtration; however, distillation and reverse osmosis eliminate nearly all of these impurities.

The drinking of purified water as a replacement of drinking water has been both advocated and discouraged for health reasons. Purified water lacks minerals and ions such as calcium that play key roles in biological functions, such as in nervous system homeostasis, and are normally found in potable water. The lack of naturally-occurring minerals in distilled water has raised some concerns. The Journal of General Internal Medicine^[23] published a study on the mineral contents of different waters available in the US. The study found that "drinking water sources available to North Americans may contain high levels of calcium, magnesium, and sodium and may provide clinically important portions of the recommended dietary intake of these minerals". It encouraged people to "check the mineral content of their drinking water, whether tap or bottled, and choose water most appropriate for their needs". Since distilled water is devoid of minerals, supplemental mineral intake through diet is needed to maintain proper health.

The consumption of "hard" water (water with minerals) is associated with beneficial cardiovascular effects. As noted in the American Journal of Epidemiology, the consumption of hard drinking water is negatively correlated with atherosclerotic heart disease.^[24]

See also

• Artificial seawater
• Hydrogen production
• Water ionizer
• Electrodeionization
• Atmospheric water generator
• Heavy water
• Water softening
• Milli-Q water

References

External links

• Deionization Interactive tutorial from the National High Magnetic Field Laboratory