Dopamine releasing agent

A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain.

No selective DRAs are currently known. Many releasing agents of both dopamine and norepinephrine (norepinephrine-dopamine releasing agents, or NDRAs) and of serotonin, norepinephrine, and dopamine are known (serotonin-norepinephrine-dopamine releasing agents, or SNDRAs), however. Examples of NDRAs include amphetamine and methamphetamine, and an example of an SNDRA is MDMA. These drugs are frequently encountered as drugs of abuse.

A closely related type of drug is a dopamine reuptake inhibitor (DRI). Various selective DRIs are known, in contrast to the case of DRAs.

There is some, albeit mixed, in vitro evidence that the antidepressant and modestly selective DRI amineptine may in addition to inhibiting the reuptake of dopamine selectively induce the presynaptic release of dopamine without affecting that of norepinephrine or serotonin.[1][2][3]

See also

References

  1. ↑ J. K. Aronson (2009). Meyler's Side Effects of Psychiatric Drugs. Elsevier. pp. 29–. ISBN 978-0-444-53266-4.
  2. ↑ Ceci, A.; Garattini, S.; Gobbi, M.; Mennini, T. (1986). "Effect of long term amineptine treatment on pre- and postsynaptic mechanisms in rat brain". British Journal of Pharmacology 88 (1): 269–275. doi:10.1111/j.1476-5381.1986.tb09495.x. ISSN 0007-1188.
  3. ↑ Bonnet, J. -J.; Chagraoui, A.; Protais, P.; Costentin, J. (1987). "Interactions of amineptine with the neuronal dopamine uptake system: Neurochemicalin vitro andin vivo studies". Journal of Neural Transmission 69 (3-4): 211–220. doi:10.1007/BF01244342. ISSN 0300-9564.



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