Diphenadione

Diphenadione

Names
IUPAC name 2-(Diphenylacetyl)-1H-indene-1,3(2H)-dione
Other names Diphacinone; Diphenandione
Identifiers
CAS Number	82-66-6 Y
ChEMBL	ChEMBL1413199
ChemSpider	6463
Jmol interactive 3D	Image
KEGG	D07136 Y
PubChem	6719
UNII	54CA01C6JX Y
InChI InChI=1S/C23H16O3/c24-21-17-13-7-8-14-18(17)22(25)20(21)23(26)19(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,19-20H Key: JYGLAHSAISAEAL-UHFFFAOYSA-N InChI=1/C23H16O3/c24-21-17-13-7-8-14-18(17)22(25)20(21)23(26)19(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,19-20H Key: JYGLAHSAISAEAL-UHFFFAOYAR
SMILES O=C2c1ccccc1C(=O)C2C(=O)C(c3ccccc3)c4ccccc4
Properties
Chemical formula	C23H16O3
Molar mass	340.38 g·mol−1
Pharmacology
ATC code	B01AA10
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)
Infobox references

Diphenadione is a vitamin K antagonist which has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other rodents. This chemical compound is an anti-coagulant with longer activity than warfarin and other synthetic indandione anticoagulants.^[1]

Safety and toxicity

Diphenadione is highly toxic for human skin by all means of contact. Consumption of the drug may cause major blood clotting abnormalities and irregular heartbeats.^[2] An online pesticide database gives more information about the safety of diphenadione.^[3] The U.S. Environmental Protection Agency has issued a safety handbook which explains how incidents of poisoning with similar rodenticides are usually treated.^[4] For treatment purposes Vitamin K antagonists like diphenadione are placed under the heading of coumarins and indandiones. The handbook notes that "...as agents specifically designed to kill mammals, often their toxicity is very similar for the target rodents and for humans."^[5]

References