4-hydroxy-tetrahydrodipicolinate reductase

4-hydroxy-tetrahydrodipicolinate reductase
Identifiers
EC number 1.17.1.8
CAS number 9055-46-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) is an enzyme that catalyzes the chemical reaction

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O \rightleftharpoons (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+

The 3 substrates of this enzyme are (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, NAD+ or NADP+, and H2O, whereas its 3 products are (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, NADH or NADPH, and H+.

This enzyme participates in lysine biosynthesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase. Other names in common use include:

References

    Further reading

    • Farkas W, Gilvarg C (Dec 1965). "The reduction step in diaminopimelic acid biosynthesis". The Journal of Biological Chemistry 240 (12): 4717–22. PMID 4378965. 
    • Tamir H (1971). "Dihydrodipicolinic acid reductase (Escherichia coli)". Methods Enzymol. 17B: 134–139. doi:10.1016/0076-6879(71)17030-9. 
    • Devenish SR, Blunt JW, Gerrard JA (Jun 2010). "NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase". Journal of Medicinal Chemistry 53 (12): 4808–12. doi:10.1021/jm100349s. PMID 20503968. 


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