Diacylglycerol cholinephosphotransferase

diacylglycerol cholinephosphotransferase
Identifiers
EC number 2.7.8.2
CAS number 9026-13-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is an enzyme that catalyzes the chemical reaction

CDP-choline + 1,2-diacylglycerol \rightleftharpoons CMP + a phosphatidylcholine

Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.[1]

Classification

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups.

Nomenclature

The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include:

  • 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase,
  • 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase,
  • 1-alkyl-2-acetylglycerol cholinephosphotransferase,
  • alkylacylglycerol choline phosphotransferase,
  • alkylacylglycerol cholinephosphotransferase,
  • CDP-choline diglyceride phosphotransferase,
  • cholinephosphotransferase,
  • CPT,
  • cytidine diphosphocholine glyceride transferase,
  • cytidine diphosphorylcholine diglyceride transferase,
  • diacylglycerol choline phosphotransferase,
  • phosphocholine diacylglyceroltransferase,
  • phosphorylcholine-glyceride transferase, and
  • sn-1,2-diacylglycerol cholinephosphotransferase.

Biological role

This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References

  1. Coleman R, Bell RM (1977). "Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities". J. Biol. Chem. 252 (9): 30506. PMID 192727.


This article is issued from Wikipedia - version of the Sunday, February 14, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.