List of designer drugs

Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal. Some designer drug (research chemicals) are structural analogues of psychoactive tryptamines or phenethylamines but there are many other chemically unrelated psychoactive substances that can be considered part of the designer drug group.[1][2][3][4] Designer drugs also include analogues of controlled anabolic steroids. The pharmaceutical activities of these compounds might not be predictable based strictly upon structural examination. Many of the substances have common effects while structurally different or different effects while structurally similar due to SAR paradox. As a result of no real official naming for some of these compounds, as well as regional naming, this can all lead to potentially hazardous mix ups for users.[5] The following list is not exhaustive.

Psychedelics

A psychedelic substance is a psychoactive drug whose primary action is to alter cognition and perception. Psychedelics tend to affect and explore the mind in ways that result in the experience being qualitatively different from those of ordinary consciousness. The psychedelic experience is often compared to non-ordinary forms of consciousness such as trance, meditation, yoga, religious ecstasy, dreaming and even near-death experiences.

Lysergamides

Lysergamides are amide derivatives of the alkaloid lysergic acid.

  • 1P-ETH-LAD, 1-Propionyl-ETH-LAD
  • 1P-LSD, 1-Propionyl-LSD
  • ALD-52, 1-Acetyl-LSD
  • AL-LAD, 6-Allyl-6-Nor-LSD
  • ETH-LAD, 6-Ethyl-6-Nor-LSD
  • LSM-775, N-Morpholinyllysergamide
  • LSZ, LA-SS-Az

Tryptamines

Drugs containing the tryptamine moiety are typically substrates for the serotonin receptors, in keeping with their close structural resemblance to serotonin, a neurotransmitter.

Benzofurans

Phenethylamines

Drugs containing the phenethylamine moiety bear close structural resemblance to dopamine but substitution on the benzene ring gives rise to drugs with a much higher affinity for serotonin receptors.

2C-x

2C-x class of psychedelics are 2,5-dimethoxy-phenethylamine derivatives.

NBxx

DOx

The DOx family of psychedelics are also known as "substituted amphetamines" as they contain the amphetamine backbone but are substituted on the benzene ring. This gives rise to serotonin agonists similar to the 2C-X class but more resistant to elimination in the body.

Dissociatives

Dissociatives are a class of hallucinogens which distort perceptions of sight and sound and produce feelings of detachment - dissociation - from the environment and self. This is done through reducing or blocking signals to the conscious mind from other parts of the brain. Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances. Some, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing euphoria. Many dissociatives have general depressant effects and can produce sedation, respiratory depression, analgesia, anesthesia, and ataxia, as well as cognitive and memory impairment and amnesia.

Arylcyclohexylamines

Arylcyclohexylamines are the oldest and most widely used dissociatives. The class includes the well known anaesthetic, ketamine.

Diarylethylamines

Diarylethylamines began to appear on grey markets only as recently as 2013.

Misc

Piperazines

Piperazine containing designer drugs have effects similar to MDMA (ecstasy). This class of drugs are mimics of serotonin that activate 5-HT receptor subtypes that release norepinephrine and dopamine.

Empathogens

Empathogens are a class of psychoactive drugs that produce distinctive emotional and social effects similar to those of MDMA . Users of empathogens say the drugs often produce feelings of empathy, love, and emotional closeness to others.

MDxx

Substituted methylenedioxyphenethylamines (MDxx) are a large chemical class of derivatives of the phenethylamines, which includes many psychoactive drugs that act as entactogens, psychedelics, and/or stimulants, as well as entheogens.

Benzofurans

Benzofurans are similar in structure to MD(M)A but differ in that the methylenedioxy groups have been modified, removing one of the two oxygens in the methylenedioxy ring to render a benzofuran ring.

Miscellaneous polycyclic phenethylamines

Indane and tetralin-type phenethylamines are vaguely related to their amphetamine analogues but tend not to display neurotoxicity.

Only one non-tryptamine indole has been sold, 5-API. It shows strong MAOI activity.

Tryptamines

Drugs containing the tryptamine moiety are typically substrates for the serotonin receptors, in keeping with their close structural resemblance to serotonin, a neurotransmitter.

  • αET, α-Ethyltryptamine, "Monase"
  • 5-MeO-αET, α,O-Diethylserotonin
  • αMT, α-Methyltryptamine, "Indopan"
  • 5-MeO-αMT, α,O-Dimethylserotonin

Amphetamines

Substituted amphetamines are a chemical class of stimulants, entactogens, hallucinogens, and other drugs. They feature a phenethylamine core with a methyl group attached to the alpha carbon resulting in amphetamine, along with additional substitutions.

  • 4-BA, 4-Bromoamphetamine, PBA
  • 4-CA, 4-Chloroamphetamine, PCA
  • 4-CMA, 4-Chloromethamphetamine, PCMA
  • 4-FA, 4-Fluoroamphetamine, PFA
  • 4-FMA, 4-Fluoromethamphetamine, PFMA
  • 4-MA, 4-Methylamphetamine, PAL-313
  • 4-MeOA, 4-Methoxyamphetamine, PMA, 4-MeO-A, "Death"
  • 4-MeOMA, 4-Methoxymethamphetamine, PMMA, 4-MeO-MA
  • 4-MTA, 4-Methylthioamphetamine
  • Methamnetamine, N-Methyl-PAL-287, Methylnaphetamine, MNT, MNA
  • MMA, 3-Methoxy-4-Methylamphetamine

Piperidines

Stimulants

Stimulants produce a variety of different kinds of effects by enhancing the activity of the central and peripheral nervous systems. Common effects, which vary depending on the substance and dosage in question, may include enhanced alertness, awareness, wakefulness, endurance, productivity, and motivation, increased arousal, locomotion, heart rate, and blood pressure, and the perception of a diminished requirement for food and sleep.

Amphetamines

Amphetamines are a chemical class of stimulants, entactogens, hallucinogens, and other drugs. They feature a phenethylamine core with a methyl group attached to the alpha carbon resulting in amphetamine, along with additional substitutions.

Cathinones

Cathinones include some stimulants and entactogens, which are derivatives of cathinone. They feature a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon, along with additional substitutions.

  • 2-Fluoromethcathinone, 2-FMC[27]
  • 2-Methylethcathinone, 2-MEC[28]
  • 2-Methylmethcathinone, 2-MMC[29]
  • 2,4-Dimethylethcathinone, 2,4-DMEC[30]
  • 2,4-Dimethylmethcathinone, 2-Methylmephedrone, 2,4-DMMC[31]
  • 3,4-Dimethylmethcathinone, 3,4-DMMC
  • 3,4-Dimethyl-N-ethylbuphedrone, 3,4-DMNEB[16]
  • 3,4-Dimethyl-N-ethylpentedrone, 3,4-DMNPD[16]
  • 3-Chloromethcathinone, 3-CMC, Metaclephedrone, Clophedrone[32]
  • 3-Ethylethcathinone, 3-EEC[33]
  • 3-Fluoromethcathinone, 3-FMC
  • 3-Methoxymethcathinone, 3-MeOMC[34]
  • 3-Methylethcathinone, 3-MEC[35]
  • 3-Methylmethcathinone, 3-MMC
  • 4-Bromomethcathinone, 4-Bromomethcathinone, 4-BMC, Brephedrone
  • 4-Bromoethcathinone, 4-BEC[36]
  • 4-Chlorodimethylcathinone, 4-CDMC
  • 4-Chloroethcathinone, 4-CEC[37]
  • 4-Chloroisopropylcathinone, 4-CiPC
  • 4-Chloromethcathinone, 4-CMC, Clephedrone[38]
  • 4-Ethylethcathinone, 4-EEC
  • 4-Ethylmethcathinone, 4-EMC
  • 4-Fluoroethylmethcathinone, 4-EFMC
  • 4-Fluoromethcathinone, Flephedrone, 4-FMC
  • 4-Fluoro-NiPP, 4F-IVP, 4-Fluoro-N-Isopropylpentedrone, 4-Fluoro-α-Isopropylamino-Valerophenone, 4-Fluoro-iPAVP, 4-Fluoro-NPP[39]
  • 4-Fluoro-Piperidinopentiophenone, 4F-PPP
  • 4-Fluoropentedrone, 4-FPD [40]
  • 4-Methyl-α-Ethylaminopentiophenone, 4-MEAPP, N-Ethyl-4-Methylpentedrone[41]
  • 4-Methylbuphedrone, 4-MeMABP, BZ-6378
  • 4-Methylcathinone, 4-MC, Normephedrone
  • 4-Methyldimethcathinone, 4-MDMC [42]
  • 4-Methylethcathinone, 4-MEC
  • 4-Methylpentedrone, 4-MPD
  • 4-Methylpropylcathinone, 4-MPC
  • 4-Sulfonyldimethcathinone, 4-SMC, 4-SDMC
  • Benzedrone, 4-MBC
  • Buphedrone, α-Methylamino-Butyrophenone, MABP
  • DL-4662, Dimethoxyethylpentedrone, VEVP[43]
  • Ephylone, N-Ethylpentylone, βk-Ethyl-K, βk-EBDP
  • Ethcathinone, EC
  • Hexedrone, α-Methylamino-Caprophenone
  • 4-Methylmethcathinone, Mephedrone, 4-MMC, 4-Methylephedrone, "MCAT"
  • 4-Methoxymethcathinone, Methedrone, βk-PMMA, 4-Methoxyephedrone, 4-MeoMC
  • Mexedrone
  • N,N-Diethyl-4-Methcathinone, N,N-DEMC
  • N-Ethylbuphedrone, NEB
  • N-Ethylhexedrone, NEH
  • N-Ethylpentedrone, NEPD
  • 4-Fluoro-N-Ethylbuphedrone, 4-Fluoro-NEB, 4-FNEB
  • NiPP, α-Isopropylamino-Valerophenone, iPAVP, N-Isopropylpentedrone, NPP[44]
  • Pentedrone, α-Methylamino-Valerophenone, MAVP, PD
  • α-Ethylaminopentiophenone, EAPP, N-Ethylpentedrone[41]
  • βk-IBP, Indanyl-N-ethylbuphedrone[16]
  • βk-IVP, Indanyl-N-ethylpentedrone[16][45]

Pyrrolidines and Pyrrolidinophenones

Pyrrolidines are amphetamines with a pyrrolidine group. Pyrrolidinophenones (also called Pyrovalerones) are cathinones (βk-amphetamines) with a pyrrolidine group.

Thiophenes

Thiophenes are stimulant drugs which are analogues of amphetamine or cathinone where the phenyl ring has been replaced by thiophene.

Tropanes and Piperidines

Tropane alkaloids occur in plants of the families erythroxylaceae (including coca). Piperidine and its derivatives are ubiquitous building blocks in the synthesis of many pharmaceuticals and fine chemicals.

Oxazolidines

Oxazolidines are a five-membered ring compounds consisting of three carbons, a nitrogen, and an oxygen. The oxygen and NH are the 1 and 3 positions, respectively. In oxazolidine derivatives, there is always a carbon between the oxygen and the nitrogen.

Cyclopropanes

Cyclopropane is a cycloalkane molecule with the molecular formula C3H6, consisting of three carbon atoms linked to each other to form a ring, with each carbon atom bearing two hydrogen atoms resulting in D3h molecular symmetry. Cyclopropane rings are found in numerous biomolecules and pharmaceutical drugs.

  • 2-PTC, 2-(4-methylphenyl)-cyclopropanamine
  • 3,4-DFPTC, 2-(3,4-difluorophenyl)-cyclopropanamine

Phenylmorpholines

Phenylmorpholines are a class of stimulants containing a phenethylamine skeleton in which the terminal amine is incorporated into a morpholine ring.

  • Isophenmetrazine, PAL-730[56]
  • 2-Hydroxy-4'-Ethylphenmetrazine, 2-HO-4'-EPM, 2-Hydroxyphenmetetrazine, N-Ethylphenmetrazol
  • 3,4-Methylenedioxyphendimetrazine, MDMPM
  • 3-Fluorophenetrazine, 3-FPE[57]
  • 3-Fluorophenmetrazine, 3-FPM, PAL-593
  • 3-Methylphenmetrazine, 3-MPM, PAL-773
  • N-Ethylphenmetrazine, Phenmetetrazine[58]
  • 4-Methylphenmetrazine, 4-MPM
  • 6-Methylphenmetrazine, 6-MPM
  • G-130
  • Methylmorphenate
  • PDM-35, 5-Methylphenmetrazine, 5-MPM
  • Phenetrazine, PE[59]
  • Viloxazine

Phenylacetamides

  • 2-PA, 2-Phenylacetamide
  • 2-PTA, 2-(4-methylphenyl)acetamide

Misc

Sedatives

Sedatives are substances that induces sedation by reducing irritability or excitement. At higher doses they may result in slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. Doses of sedatives such as benzodiazepines, when used as a hypnotic to induce sleep, tend to be higher than amounts used to relieve anxiety, whereas only low doses are needed to provide a peaceful effect. Sedatives can be misused to produce an overly-calming effect. In the event of an overdose or if combined with another sedative, many of these drugs can cause unconsciousness and even death.

Opioids

Opioids have pharmacologic actions resembling morphine and other components of opium.

Benzodiazepines

Thienodiazepines

GHB analogues

Methaqualone analogues

Misc

Synthetic cannabimimetics

Main article: Synthetic cannabinoid

Agonists of the central cannabinoid receptor type 1 mimic the behavioral effects of cannabis.

Classical cannabinoids

Miscellaneous cannabinoids

Indazole based

Indazole containing cannabinoid receptor agonists include:

Indole based

Indole containing cannabinoid receptor agonists include:

Quinolinylindoles

Benzoylindoles

Adamantoylindoles

Naphthoylindoles

Phenylacetylindoles

Androgens

Androgenic anabolic steroids have approved medical uses as well as used illicitly as performance-enhancing drugs to build muscle mass and strength. Anabolic steroids that have been designed to evade detection in sport doping tests are known as "designer steroids".[83][84]

Testosterone based

DHT based

Estranes

SARMs

Selective androgen receptor modulators (SARMs) are a novel class of androgen receptor ligands. They are intended to maintain the desirable muscle building effects of anabolic steroids while reducing undesirable androgenic actions (e.g., increased risk of prostate cancer). SARMs that are more selective in their action potentially could be used for a wider range clinical indications than the relatively limited legitimate uses that anabolic steroids are currently approved for.[85]

Others

Peptides

GHRH analogues

GHRH analogues stimulate the release of growth hormone.

Growth hormone secretagogue receptor agonists

Agonists of the growth hormone secretagogue receptor regulate energy homeostasis and body weight.

Others

PDE5 inhibitors

PDE5 inhibitors are typically used to treat erectile dysfunction and improve sexual stamina.

Nootropics

Nootropics are drugs that improve one or more aspects of mental function, such as working memory, motivation, and attention.

Racetams

Racetams are a class of drugs that share a pyrrolidone nucleus. Many, such as piracetam, but not all, are considered nootropics.

References

  1. ↑ "EMCDDA–Europol 2013 Annual Report on the information exchange, risk assessment and control of new psychoactive substances (implementation of Council Decision 2005/387/JHA)". EMCDDA. July 2014. Retrieved 8 August 2014.
  2. ↑ "EMCDDA–Europol 2012 Annual Report on the implementation of Council Decision 2005/387/JHA (New drugs in Europe, 2012)". EMCDDA. May 2013. Retrieved 8 August 2014.
  3. ↑ "EMCDDA–Europol 2011 Annual Report on the (information exchange, risk assessment and control of new psychoactive substances) implementation of Council Decision 2005/387/JHA". EMCDDA. April 2012. Retrieved 8 August 2014.
  4. ↑ "EMCDDA–Europol 2010 Annual Report on the implementation of Council Decision 2005/387/JHA". EMCDDA. May 2011. Retrieved 8 August 2014.
  5. ↑ Shimizu E, Watanabe H, Kojima T, Hagiwara H, Fujisaki M, Miyatake R, Hashimoto K, Iyo M (Jan 2007). "Combined intoxication with methylone and 5-MeO-MIPT". Progress in Neuro-Psychopharmacology & Biological Psychiatry 31 (1): 288–91. doi:10.1016/j.pnpbp.2006.06.012. PMID 16876302.
  6. ↑ "4-AcO-DPT". PubChem.
  7. ↑ "4-HO-DALT". Isomerdesign.
  8. ↑ Uchiyama N, Miyazawa N, Kawamura M, Kikura-Hanajiri R, Goda Y (2010). "[Analysis of newly distributed designer drugs detected in the products purchased in fiscal year 2008]". Yakugaku Zasshi (in Japanese) 130 (2): 263–70. doi:10.1248/yakushi.130.263. PMID 20118651.
  9. ↑ "5-MeO-MET". Isomerdesign.
  10. ↑ "5-MeO-NiPT". Isomerdesign.
  11. ↑ "McPT". New Synthetic Drugs Database.
  12. ↑ Daniel Trachsel, David Lehmann, Christoph Enzensperger (2013). Phenethylamine Von der Struktur zur Funktion. Nachtschatten Verlag AG. ISBN 978-3-03788-700-4.
  13. ↑ "25B-NBF". Cayman Chemical. Retrieved 27 December 2014.
  14. ↑ "25C-NBF". Cayman Chemical. Retrieved 27 December 2014.
  15. ↑ "25iP-NBOMe". New Synthetic Drugs Database.
  16. 1 2 3 4 5 6 7 Asuka Kaizaki-Mitsumoto, Naoki Noguchi, Saki Yamaguchi, Yuki Odanaka, Satoko Matsubayashi, Hiroki Kumamoto, Kiyoshi Fukuhara, Masahiko Funada, Kiyoshi Wada, Satoshi Numazawa (November 2015). "Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34, and escaline), eight cathinone derivatives, and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market". Forensic Toxicology. doi:10.1007/s11419-015-0293-6.
  17. ↑ "C30-NBOMe". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
  18. ↑ "Mescaline-NBOMe". Cayman Chemical. Retrieved 29 September 2015.
  19. ↑ "deschloro-N-ethyl-Ketamine". Cayman Chemical.
  20. ↑ Morris H, Wallach J (2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Test Anal 6 (7-8): 614–32. doi:10.1002/dta.1620. PMID 24678061.
  21. ↑ "DB-MDBP". New Synthetic Drugs Database.
  22. ↑ "Dimethylone". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
  23. ↑ "N,N-Dimethylpentylone". Cayman Chemical. Retrieved 29 September 2015.
  24. ↑ "EFLEA". New Synthetic Drugs Database.
  25. 1 2 Nahoko Uchiyama, Yoshihiko Shimokawa, Ruri Kikura-Hanajiri, Yosuke Demizu, Yukihiro Goda, Takashi Hakamatsuka (February 2015). "A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products". Forensic Toxicology. doi:10.1007/s11419-015-0268-7.
  26. ↑ "5-MBPB". New Synthetic Drugs Database.
  27. ↑ "2-FMC" (PDF). SWGDRUG. 2013. Retrieved 19 August 2014.
  28. ↑ "2-Methylethcathinone". Cayman Chemical. Retrieved 6 September 2015.
  29. ↑ "2-MMC" (PDF). SWGDRUG. 2013. Retrieved 19 August 2014.
  30. ↑ "2,4-DMEC". New Synthetic Drugs Database.
  31. ↑ "2,4-DMMC". New Synthetic Drugs Database.
  32. ↑ "3-Chloromethcathinone". Cayman Chemical. Retrieved 29 September 2015.
  33. ↑ "3-Ethylethcathinone". Cayman Chemical. Retrieved 29 September 2015.
  34. ↑ "3-MeOMC". Cayman Chemical. Retrieved 27 December 2014.
  35. ↑ "3-MEC" (PDF). SWGDRUG. 2013. Retrieved 19 August 2014.
  36. ↑ "4-BEC". New Synthetic Drugs Database.
  37. ↑ Siemer Harm (11 April 1967). "US Patent 3313687 - Appetite-suppressing and weight reducing composition".
  38. ↑ "4-CMC". Cayman Chemical. Retrieved 27 December 2014.
  39. ↑ "4F-IVP". Cayman Chemical. Retrieved 29 September 2015.
  40. ↑ "4-FPD". Cayman Chemical. Retrieved 7 April 2015.
  41. 1 2 3 4 5 Uchiyama N, Matsuda S, Kawamura M, Shimokawa Y, Kikura-Hanajiri R, Aritake K, Urade Y, Goda Y (2014). "Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products". Forensic Sci. Int. 243: 1–13. doi:10.1016/j.forsciint.2014.03.013. PMID 24769262.
  42. ↑ "4-methyl-N,N-DMC". Cayman Chemical. Retrieved 7 April 2015.
  43. ↑ Weiß JA, Taschwer M, Kunert O, Schmid MG (2014). "Analysis of a new drug of abuse: Cathinone derivative 1-(3,4-dimethoxyphenyl)-2-(ethylamino)pentan-1-one (DL-4662)". J Sep Sci 38: 825–8. doi:10.1002/jssc.201401052. PMID 25545103.
  44. ↑ "NiPP". New Synthetic Drugs Database.
  45. ↑ "βk-IVP". New Synthetic Drugs Database.
  46. ↑ Gaspar H, Bronze S, Ciríaco S, Queirós CR, Matias A, Rodrigues J, Oliveira C, Cordeiro C, Santos S (May 2015). "4F-PBP (4'-fluoro-α-pyrrolidinobutyrophenone), a new substance of abuse: Structural characterization and purity NMR profiling". Forensic Science International 252: 168–176. doi:10.1016/j.forsciint.2015.05.003. PMID 26005857.
  47. ↑ Kaori Shintani-Ishida, Mami Nakamura, Misa Tojo, Nozomi Idota, Hiroshi Ikegaya (May 2015). "Identification and quantification of 4′-methoxy-α-pyrrolidinobutiophenone (4-MeOPBP) in human plasma and urine using LC–TOF-MS in an autopsy case". Forensic Toxicology 33: 348–354. doi:10.1007/s11419-015-0281-x.
  48. ↑ "5-PPDI". New Synthetic Drugs Database.
  49. ↑ "α-PBT". Cayman Chemical. Retrieved 27 December 2014.
  50. ↑ "TH-PVP". New Synthetic Drugs Database.
  51. ↑ "5-BPDI". New Synthetic Drugs Database.
  52. ↑ "3,4-MDPHP". Cayman Chemical. Retrieved 7 April 2015.
  53. ↑ "PV-8". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
  54. ↑ "4-MeO-PV-9". Cayman Chemical. Retrieved 27 December 2014.
  55. ↑ "PV-10". Cayman Chemical. Retrieved 7 April 2015.
  56. ↑ "Isophenmetrazine". New Synthetic Drugs Database.
  57. ↑ "3-FPE". New Synthetic Drugs Database.
  58. ↑ "Phenmetetrazine". New Synthetic Drugs Database.
  59. ↑ "Phenetrazine". New Synthetic Drugs Database.
  60. ↑ Power JD, Scott KR, Gardner EA, Curran McAteer BM, O'Brien JE, Brehon M, Talbot B, Kavanagh PV (January 2014). "The syntheses, characterization and in vitro metabolism of nitracaine, methoxypiperamide and mephtetramine". Drug Testing and Analysis 6 (7-8): 668–75. doi:10.1002/dta.1616. PMID 24574100.
  61. ↑ "Modafiendz". New Synthetic Drugs Database.
  62. ↑ "W-15". Forendex. Southern Association of Forensic Scientists. Retrieved 8 July 2015.
  63. ↑ Laura M. Huppertz, Philippe Bisel, Folker Westphal, Florian Franz, Volker Auwärter, Bjoern Moosmann (April 2015). "Characterization of the four designer benzodiazepines clonazolam, deschloroetizolam, flubromazolam, and meclonazepam, and identification of their in vitro metabolites". Forensic Toxicology 33: 388–395. doi:10.1007/s11419-015-0277-6.
  64. ↑ "EG-018". Cayman Chemical. Retrieved 9 August 2014.
  65. ↑ "EG-2201". Cayman Chemical. Retrieved 27 October 2015.
  66. ↑ "MDMB-CHMCZCA". New Synthetic Drugs Database.
  67. ↑ "5C-APINACA". New Synthetic Drugs Database.
  68. ↑ "5F-MN-18". Forendex. Southern Association of Forensic Scientists. Retrieved 12 August 2014.
  69. ↑ "5F-NPB-22". Cayman Chemical. Retrieved 9 May 2015.
  70. ↑ "5F-SDB-005". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
  71. 1 2 Zhenhua Qian, Zhendong Hua, Cuimei Liu, Wei Jia (November 2015). "Four types of cannabimimetic indazole and indole derivatives, ADB-BINACA, AB-FUBICA, ADB-FUBICA, and AB-BICA, identified as new psychoactive substances". Forensic Toxicology. doi:10.1007/s11419-015-0297-2.
  72. ↑ "AMB". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
  73. ↑ Jun’ichi Nakajima, Misako Takahashi, Nozomi Uemura, Takako Seto, Haruhiko Fukaya, Jin Suzuki, Masao Yoshida, Maiko Kusano, Hiroshi Nakayama, Kei Zaitsu, Akira Ishii, Takako Moriyasu, Dai Nakae (November 2014). "Identification of N,N-bis(1-pentylindol-3-yl-carboxy)naphthylamine (BiPICANA) found in an herbal blend product in the Tokyo metropolitan area and its cannabimimetic effects evaluated by in vitro [35S]GTPγS binding assays". Forensic Toxicology 33: 84–92. doi:10.1007/s11419-014-0253-6.
  74. ↑ "EMB-FUBINACA". New Synthetic Drugs Database.
  75. ↑ "FUB-NPB-22". Cayman Chemical. Retrieved 9 May 2015.
  76. ↑ Shevyrin V, Melkozerov V, Nevero A, Eltsov O, Shafran Y, Morzherin Y, Lebedev AT (Apr 2015). "Identification and analytical characteristics of synthetic cannabinoids with an indazole-3-carboxamide structure bearing a N-1-methoxycarbonylalkyl group". Analytical and Bioanalytical Chemistry 407: 6301–15. doi:10.1007/s00216-015-8612-7. PMID 25893797.
  77. ↑ "NPB-22". Cayman Chemical. Retrieved 9 May 2015.
  78. ↑ Samuel D Banister, Michael Moir, Jordyn Stuart, Richard C Kevin, Katie E Wood, Mitchell Longworth, Shane M Wilkinson, Corinne Beinat, Alxendra S Buchanan, Michelle Glass, Mark Connor, Iain S McGregor, Michael Kassiou (July 2015). "The pharmacology of indole and indazole synthetic cannabinoid designer drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA and 5F-ADBICA". ACS Chemical Neuroscience 6: 1546–59. doi:10.1021/acschemneuro.5b00112. PMID 26134475.
  79. ↑ "5F-PY-PICA". New Synthetic Drugs Database.
  80. ↑ "AMB-CHMICA". New Synthetic Drugs Database.
  81. ↑ "CBL-018". Cayman Chemical. Retrieved 26 October 2015.
  82. ↑ Jenny L. Wiley, Timothy W. Lefever, Ricardo A. Cortes, Julie A. Marusich (September 2014). "Cross-substitution of Δ9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats". Pharmacology Biochemistry and Behavior 124: 123–128. doi:10.1016/j.pbb.2014.05.016. PMID 24887450.
  83. ↑ Kazlauskas R (2010). "Designer steroids". Handb Exp Pharmacol 195 (195): 155–85. doi:10.1007/978-3-540-79088-4_7. PMID 20020364.
  84. ↑ Abushareeda W, Fragkaki A, Vonaparti A, Angelis Y, Tsivou M, Saad K, Kraiem S, Lyris E, Alsayrafi M, Georgakopoulos C (2014). "Advances in the detection of designer steroids in anti-doping". Bioanalysis 6 (6): 881–96. doi:10.4155/bio.14.9. PMID 24702116.
  85. ↑ Zhang X, Sui Z (2013). "Deciphering the selective androgen receptor modulators paradigm". Expert Opin Drug Discov 8 (2): 191–218. doi:10.1517/17460441.2013.741582. PMID 23231475.
  86. ↑ Zhang X, Li X, Allan GF, Sbriscia T, Linton O, Lundeen SG, Sui Z (January 2007). "Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators". Bioorg. Med. Chem. Lett. 17 (2): 439–43. doi:10.1016/j.bmcl.2006.10.035. PMID 17079140.
  87. ↑ Allan GF, Tannenbaum P, Sbriscia T, Linton O, Lai MT, Haynes-Johnson D, Bhattacharjee S, Zhang X, Sui Z, Lundeen SG (2007). "A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats". Endocrine 32 (1): 41–51. doi:10.1007/s12020-007-9005-2. PMID 17992601.
  88. ↑ Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y (2013). "Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression". Biol. Pharm. Bull. 36 (9): 1460–5. doi:10.1248/bpb.b13-00231. PMID 23995658.
  89. ↑ Kentaro Takayama, Yuri Noguchi, Shin Aoki, Shota Takayama, Momoko Yoshida, Tomo Asari, Fumika Yakushiji, Shin-ichiro Nishimatsu, Yutaka Ohsawa, Fumiko Itoh, Yoichi Negishi, Yoshihide Sunada, Yoshio Hayashi (February 2015). "Brief Article Prev. Article Next Article Table of Contents Identification of the Minimum Peptide from Mouse Myostatin Prodomain for Human Myostatin Inhibition". Journal of Medicinal Chemistry 58 (3): 1544–1549. doi:10.1021/jm501170d. PMID 25569186.
  90. ↑ "Public Notification: "RigiRx Plus" Contains Undeclared Drug Ingredient". US FDA. 20 April 2012. Retrieved 15 August 2014.
  91. ↑ Zhang L, Li P, Hsu T, Aguilar HR, Frantz DE, Schneider JW, Bachoo RM, Hsieh J (Apr 2011). "Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression". Differentiation; Research in Biological Diversity 81 (4): 233–42. doi:10.1016/j.diff.2011.02.005. PMC 3752777. PMID 21419563.
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