Derrubone

Derrubone
Names
IUPAC name
3-(1,3-Benzodioxol-5-yl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)chromen-4-one
Other names
5,7-Dihydroxy-3',4'-methylenedioxy-6-prenylisoflavone
Identifiers
22044-58-2 N
ChEMBL ChEMBL412010 N
ChemSpider 4709237 N
Jmol interactive 3D Image
PubChem 5810067
Properties
C21H18O6
Molar mass 366.37 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Derrubone is a prenylated isoflavone, a type of flavonoid. It was originally isolated from the Indian tree Derris robusta.[1] Recent research indicates that it acts as an inhibitor of Hsp90 to its function as a chaperone protein.[2]

References

  1. East AJ, Ollis WD, Wheeler RE (1969). "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of Derris robusta(roxb.) benth.". J. Chem. Soc. C 3: 365–74. doi:10.1039/J39690000365.
  2. Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS (December 2007). "Derrubone, an inhibitor of the Hsp90 protein folding machinery". J. Nat. Prod. 70 (12): 2014–8. doi:10.1021/np070190s. PMID 18020309.
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