David Little
David Little may refer to:
- David Little (linebacker) (1959–2005), former professional American football linebacker for the Pittsburgh Steelers
- David Little (tight end) (born 1961), former professional American football tight end for the Philadelphia Eagles
- David "Tex" Little (1902– 2006), American veteran who served during the First World War
- David John Little, MP in the Northern Ireland Parliament for West Down
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