DNA-3-methyladenine glycosylase I
DNA-3-methyladenine glycosylase I (EC 3.2.2.20, deoxyribonucleate 3-methyladenine glycosidase I, 3-methyladenine DNA glycosylase I, DNA-3-methyladenine glycosidase I) is an enzyme with system name alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine).[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of alkylated DNA, releasing 3-methyladenine
This enzyme is involved in the removal of alkylated bases from DNA in Escherichia coli.
References
- ↑ Evensen, G. and Seeberg, E. (1982). "Adaptation to alkylation resistance involves the induction of a DNA glycosylase". Nature 296: 773–775. doi:10.1038/296773a0. PMID 7040984.
- ↑ Karran, P., Hjelmgren, T. and Lindahl, T. (1982). "Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents". Nature 296: 770–773. doi:10.1038/296770a0. PMID 7040983.
- ↑ Thomas, L., Yang, C.-H. and Goldthwait, D.A. (1982). "Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine". Biochemistry 21: 1162–1169. doi:10.1021/bi00535a009. PMID 7041972.
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