DLX2

Distal-less homeobox 2

PDB rendering based on 2djn.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2djn

Identifiers

Symbols

DLX2 ; TES-1; TES1

External IDs

OMIM: 126255 MGI: 94902 HomoloGene: 3244 GeneCards: DLX2 Gene

Gene ontology
Molecular function	• RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • single-stranded RNA binding • protein binding
Cellular component	• nucleus
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • brain development • proximal/distal pattern formation • subpallium development • hippocampus development • olfactory bulb development • regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment • cerebral cortex GABAergic interneuron fate commitment • odontogenesis of dentin-containing tooth • negative regulation of Notch signaling pathway • positive regulation of transcription from RNA polymerase II promoter • embryonic cranial skeleton morphogenesis • negative regulation of oligodendrocyte differentiation • branching morphogenesis of a nerve • cartilage development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
172.1 – 172.1 Mb

Chr 2:
71.54 – 71.55 Mb

PubMed search

Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.^[1]^[2]

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.^[2]

Interactions

DLX2 has been shown to interact with DLX5,^[3] MSX1^[3] and Msh homeobox 2.^[3]

References

↑ Ozcelik T, Porteus MH, Rubenstein JL, Francke U (Sep 1992). "DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2". Genomics 13 (4): 1157–61. doi:10.1016/0888-7543(92)90031-M. PMID 1354641.
1 2 "Entrez Gene: DLX2 distal-less homeobox 2".
1 2 3 Zhang, H; Hu G; Wang H; Sciavolino P; Iler N; Shen M M; Abate-Shen C (May 1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. (UNITED STATES) 17 (5): 2920–32. ISSN 0270-7306. PMC 232144. PMID 9111364.

Harris SE, Guo D, Harris MA; et al. (2003). "Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors". Front. Biosci. 8: s1249–65. doi:10.2741/1170. PMID 12957859.
Qiu M, Bulfone A, Martinez S; et al. (1995). "Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain". Genes Dev. 9 (20): 2523–38. doi:10.1101/gad.9.20.2523. PMID 7590232.
Selski DJ, Thomas NE, Coleman PD, Rogers KE (1993). "The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue". Gene 132 (2): 301–3. doi:10.1016/0378-1119(93)90212-L. PMID 7901126.
Simeone A, Acampora D, Pannese M; et al. (1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc. Natl. Acad. Sci. U.S.A. 91 (6): 2250–4. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794.
McGuinness T, Porteus MH, Smiga S; et al. (1996). "Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus". Genomics 35 (3): 473–85. doi:10.1006/geno.1996.0387. PMID 8812481.
Zhang H, Hu G, Wang H; et al. (1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. 17 (5): 2920–32. PMC 232144. PMID 9111364.
Yu G, Zerucha T, Ekker M, Rubenstein JL (2002). "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins". Brain Res. Dev. Brain Res. 130 (2): 217–30. doi:10.1016/S0165-3806(01)00239-5. PMID 11675124.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Espinoza HM, Ganga M, Vadlamudi U; et al. (2005). "Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein". Biochemistry 44 (10): 3942–54. doi:10.1021/bi048362x. PMID 15751970.

PDB gallery

2djn: The solution structure of the homeobox domain of human Homeobox protein DLX-5

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DLX2

Interactions

References

Further reading