DLST

Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)

Identifiers

DLST ; DLTS

External IDs

OMIM: 126063 MGI: 1926170 HomoloGene: 1456 GeneCards: DLST Gene

2.3.1.61

Gene ontology
Molecular function	• dihydrolipoyllysine-residue succinyltransferase activity • heat shock protein binding • chaperone binding
Cellular component	• nucleus • mitochondrial matrix • plasma membrane • membrane • myelin sheath • oxoglutarate dehydrogenase complex • extracellular exosome
Biological process	• generation of precursor metabolites and energy • tricarboxylic acid cycle • 2-oxoglutarate metabolic process • lysine catabolic process • NADH metabolic process • L-lysine catabolic process to acetyl-CoA via saccharopine • cellular nitrogen compound metabolic process • cellular metabolic process • small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
74.88 – 74.9 Mb

Chr 12:
85.11 – 85.13 Mb

PubMed search

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial is an enzyme that in humans is encoded by the DLST gene.^[1]^[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=TCA Cycle edit]]

TCA Cycle edit

↑ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78".

References

↑ Ali G, Wasco W, Cai X, Szabo P, Sheu KF, Cooper AJ, Gaston SM, Gusella JF, Tanzi RE, Blass JP (Jul 1994). "Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex". Somat Cell Mol Genet 20 (2): 99–105. doi:10.1007/BF02290679. PMID 8009371.
↑ "Entrez Gene: DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)".

Chuang DT, Fisher CW, Lau KS; et al. (1991). "Maple syrup urine disease: domain structure, mutations and exon skipping in the dihydrolipoyl transacylase (E2) component of the branched-chain alpha-keto acid dehydrogenase complex.". Mol. Biol. Med. 8 (1): 49–63. PMID 1943690.
Fregeau DR, Prindiville T, Coppel RL; et al. (1990). "Inhibition of alpha-ketoglutarate dehydrogenase activity by a distinct population of autoantibodies recognizing dihydrolipoamide succinyltransferase in primary biliary cirrhosis.". Hepatology 11 (6): 975–81. doi:10.1002/hep.1840110611. PMID 2365294.
Ono K, Hakozaki M, Kimura A, Kochi H (1987). "Purification, resolution, and reconstitution of rat liver branched-chain alpha-keto acid dehydrogenase complex.". J. Biochem. 101 (1): 19–27. PMID 3571202.
Kochi H, Seino H, Ono K (1986). "Inhibition of glycine oxidation by pyruvate, alpha-ketoglutarate, and branched-chain alpha-keto acids in rat liver mitochondria: presence of interaction between the glycine cleavage system and alpha-keto acid dehydrogenase complexes.". Arch. Biochem. Biophys. 249 (2): 263–72. doi:10.1016/0003-9861(86)90002-0. PMID 3753002.
Nakano K, Takase C, Sakamoto T; et al. (1994). "Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex.". Eur. J. Biochem. 224 (1): 179–89. doi:10.1111/j.1432-1033.1994.tb20010.x. PMID 8076640.
Nakano K, Takase C, Sakamoto T; et al. (1993). "An unspliced cDNA for human dihydrolipoamide succinyltransferase: characterization and mapping of the gene to chromosome 14q24.2-q24.3.". Biochem. Biophys. Res. Commun. 196 (2): 527–33. doi:10.1006/bbrc.1993.2282. PMID 8240324.
Nakano K, Matuda S, Sakamoto T; et al. (1994). "Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3.". Biochim. Biophys. Acta 1216 (3): 360–8. doi:10.1016/0167-4781(93)90002-u. PMID 8268217.
Cruts M, Backhovens H, Van Gassen G; et al. (1996). "Mutation analysis of the chromosome 14q24.3 dihydrolipoyl succinyltransferase (DLST) gene in patients with early-onset Alzheimer disease.". Neurosci. Lett. 199 (1): 73–7. doi:10.1016/0304-3940(95)11982-3. PMID 8584231.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Matuda S, Kodama J, Goshi N; et al. (1998). "A polypeptide derived from mitochondrial dihydrolipoamide succinyltransferase is located on the plasma membrane in skeletal muscle.". Biochem. Biophys. Res. Commun. 241 (1): 151–6. doi:10.1006/bbrc.1997.7784. PMID 9405249.
McCartney RG, Rice JE, Sanderson SJ; et al. (1998). "Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components.". J. Biol. Chem. 273 (37): 24158–64. doi:10.1074/jbc.273.37.24158. PMID 9727038.
Sheu KF, Brown AM, Haroutunian V; et al. (1999). "Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population.". Ann. Neurol. 45 (1): 48–53. doi:10.1002/1531-8249(199901)45:1<48::AID-ART9>3.0.CO;2-V. PMID 9894876.
Ma Q, Chan P, Yang J (2002). "[Association between DLST gene polymorphism and Alzheimer's disease]". Zhonghua Yi Xue Za Zhi 81 (20): 1246–8. PMID 11825528.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kanamori T, Nishimaki K, Asoh S; et al. (2003). "Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain". EMBO J. 22 (12): 2913–23. doi:10.1093/emboj/cdg299. PMC 162151. PMID 12805207.
Brown AM, Gordon D, Lee H; et al. (2004). "Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association". Neurochem. Res. 29 (3): 629–35. doi:10.1023/B:NERE.0000014833.54481.1d. PMID 15038610.
Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Enzymes: multienzyme complexes

Photosynthesis	Photosynthetic reaction center complex proteins Photosystem I II

Dehydrogenase	Pyruvate dehydrogenase complex E1 E2 E3 Oxoglutarate dehydrogenase OGDH DLST DLD Branched-chain alpha-keto acid dehydrogenase complex BCKDHA BCKDHB DBT DLD

Other	CAD Carbamoyl phosphate synthase II Aspartate carbamoyltransferase Dihydroorotase Cholesterol side-chain cleavage enzyme Cytochrome b6f complex Electron transport chain Fatty acid synthetase complex Glycine decarboxylase complex Mitochondrial trifunctional protein HADHA HADHB Phosphoenolpyruvate sugar phosphotransferase system Polyketide synthase Sucrase-isomaltase complex Tryptophan synthase

This article is issued from Wikipedia - version of the Tuesday, May 05, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

DLST

Interactive pathway map

References

Further reading