DCUN1D1

DCN1, defective in cullin neddylation 1, domain containing 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DCUN1D1 ; DCNL1; DCUN1L1; RP42; SCCRO; SCRO; Tes3
External IDs OMIM: 605905 MGI: 2150386 HomoloGene: 10773 GeneCards: DCUN1D1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 54165 114893
Ensembl ENSG00000043093 ENSMUSG00000027708
UniProt Q96GG9 Q9QZ73
RefSeq (mRNA) NM_001308101 NM_001205361
RefSeq (protein) NP_001295030 NP_001192290
Location (UCSC) Chr 3:
182.94 – 182.99 Mb		 Chr 3:
35.89 – 35.94 Mb
PubMed search

DCN1-like protein 1 is a protein that in humans is encoded by the DCUN1D1 gene.[1][2][3]

DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells.[4][5][6]

Interactions

DCUN1D1 has been shown to interact with:

References

  1. ↑ Mas C, Bourgeois F, Bulfone A, Levacher B, Mugnier C, Simonneau M (Apr 2000). "Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16". Genomics 65 (1): 70–4. doi:10.1006/geno.2000.6126. PMID 10777668.
  2. ↑ Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M (Jun 2005). "The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae". Nature 435 (7046): 1257–61. doi:10.1038/nature03662. PMID 15988528.
  3. ↑ "Entrez Gene: DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)".
  4. ↑ Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B (Jun 2010). "SCCRO promotes glioma formation and malignant progression in mice". Neoplasia 12 (6): 476–84. doi:10.1593/neo.10202. PMC 2887088. PMID 20563250.
  5. ↑ Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B (Oct 2006). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas". Cancer Research 66 (19): 9437–44. doi:10.1158/0008-5472.CAN-06-2074. PMID 17018598.
  6. ↑ Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, Kouros-Mehr H (2014). "Identification of druggable cancer driver genes amplified across TCGA datasets". PLOS ONE 9 (5): e98293. doi:10.1371/journal.pone.0098293. PMC 4038530. PMID 24874471.
  7. 1 2 3 4 5 Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". The Journal of Biological Chemistry 283 (48): 33211–20. doi:10.1074/jbc.M804440200. PMC 2586271. PMID 18826954.

Further reading

  • Sarkaria IS, Pham D, Ghossein RA, Talbot SG, Hezel M, Dudas ME, Ebright MI, Chuai S, Memoli N, Venkatraman ES, Miller VA, Kris MG, Zakowski MF, Rusch VW, Singh B (Nov 2004). "SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma". The Annals of Thoracic Surgery 78 (5): 1734–41. doi:10.1016/j.athoracsur.2004.05.056. PMID 15511464. 
  • Estilo CL, O-Charoenrat P, Ngai I, Patel SG, Reddy PG, Dao S, Shaha AR, Kraus DH, Boyle JO, Wong RJ, Pfister DG, Huryn JM, Zlotolow IM, Shah JP, Singh B (Jun 2003). "The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue". Clinical Cancer Research 9 (6): 2300–6. PMID 12796399. 
  • Talbot SG, O-charoenrat P, Sarkaria IS, Ghossein R, Reddy P, Ngai I, Cordeiro CN, Wong RJ, Kris MG, Rusch VW, Singh B (May 2004). "Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A". Annals of Surgical Oncology 11 (5): 530–4. doi:10.1245/ASO.2004.03.014. PMID 15123463. 
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. 
  • Jacques C, Baris O, Prunier-Mirebeau D, Savagner F, Rodien P, Rohmer V, Franc B, Guyetant S, Malthiery Y, Reynier P (Apr 2005). "Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors". The Journal of Clinical Endocrinology and Metabolism 90 (4): 2314–20. doi:10.1210/jc.2004-1337. PMID 15623817. 
  • Sarkaria IS, Stojadinovic A, Talbot SG, Hoos A, Dudas ME, Brennan MF, Ghossein RA, Singh B (Dec 2004). "Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas". Surgery 136 (6): 1122–8. doi:10.1016/j.surg.2004.06.041. PMID 15657565. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B (Oct 2006). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas". Cancer Research 66 (19): 9437–44. doi:10.1158/0008-5472.CAN-06-2074. PMID 17018598. 


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