DCP1B

Decapping mRNA 1B

Identifiers

DCP1B ; DCP1; hDcp1b

External IDs

OMIM: 609843 MGI: 2442404 HomoloGene: 51881 GeneCards: DCP1B Gene

Gene ontology
Molecular function	• mRNA binding • protein binding • hydrolase activity • enzyme regulator activity
Cellular component	• cytoplasmic mRNA processing body • nucleus • cytoplasm • cytosol • membrane • intracellular membrane-bounded organelle
Biological process	• nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • deadenylation-dependent decapping of nuclear-transcribed mRNA • gene expression • deadenylation-independent decapping of nuclear-transcribed mRNA • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • regulation of catalytic activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
119.18 – 119.22 Mb

PubMed search

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene.^[1]^[2]^[3]

DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002).[supplied by OMIM]^[3]

References

↑ Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
↑ Cougot N, Babajko S, Seraphin B (Apr 2004). "Cytoplasmic foci are sites of mRNA decay in human cells". J Cell Biol 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023.
1 2 "Entrez Gene: DCP1B DCP1 decapping enzyme homolog B (S. cerevisiae)".

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Post-transcriptional modification

Nuclear

Precursor mRNA
5′ cap formation
Polyadenylation
- CPSF
- CstF
- PAP
- PAB2
- CFI
- CFII
Poly(A)-binding protein
RNA editing
Polyuridylation

RNA splicing

Intron / Exon snRNP Spliceosome minor U1 Alternative splicing

pre-mRNA factors	PLRG1 PRPF3 PRPF4 PRPF4B PRPF6 PRPF8 PRPF18 PRPF19 PRPF31 PRPF38A PRPF38B PRPF39 PRPF40A PRPF40B

Cytosolic

5′ cap methylation
mRNA decapping
- DCP1A
- DCP1B
- DCP2
- DCPS
- EDC3
- EDC4

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DCP1B

References

Further reading