DAPP1
| Dual adaptor of phosphotyrosine and 3-phosphoinositides | |||||||||||||
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PDB rendering based on 1fao. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | DAPP1 ; BAM32 | ||||||||||||
| External IDs | OMIM: 605768 MGI: 1347063 HomoloGene: 32138 GeneCards: DAPP1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 27071 | 26377 | |||||||||||
| Ensembl | ENSG00000070190 | ENSMUSG00000028159 | |||||||||||
| UniProt | Q9UN19 | Q9QXT1 | |||||||||||
| RefSeq (mRNA) | NM_001306151 | NM_011932 | |||||||||||
| RefSeq (protein) | NP_001293080 | NP_036062 | |||||||||||
| Location (UCSC) |
Chr 4: 99.82 – 99.87 Mb |
Chr 3: 137.93 – 137.98 Mb | |||||||||||
| PubMed search | |||||||||||||
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.[1][2]
References
- ↑ Dowler S, Currie RA, Downes CP, Alessi DR (Oct 1999). "DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides". Biochem J 342 (1): 7–12. doi:10.1042/0264-6021:3420007. PMC 1220429. PMID 10432293.
- ↑ "Entrez Gene: DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides".
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Marshall AJ, Niiro H, Lerner CG; et al. (2000). "A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase.". J. Exp. Med. 191 (8): 1319–32. doi:10.1084/jem.191.8.1319. PMC 2193139. PMID 10770799.
- Dowler S, Montalvo L, Cantrell D; et al. (2001). "Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase.". Biochem. J. 349 (Pt 2): 605–10. doi:10.1042/0264-6021:3490605. PMC 1221184. PMID 10880360.
- Ferguson KM, Kavran JM, Sankaran VG; et al. (2000). "Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains.". Mol. Cell 6 (2): 373–84. doi:10.1016/S1097-2765(00)00037-X. PMID 10983984.
- Dowler S, Currie RA, Campbell DG; et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
- Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Stephens LR, Anderson KE, Hawkins PT (2001). "Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines.". J. Biol. Chem. 276 (46): 42767–73. doi:10.1074/jbc.M107194200. PMID 11524430.
- Niiro H, Maeda A, Kurosaki T, Clark EA (2002). "The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival.". J. Exp. Med. 195 (1): 143–9. doi:10.1084/jem.20011524. PMC 2196019. PMID 11781373.
- Marshall AJ, Krahn AK, Ma K; et al. (2002). "TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor.". Mol. Cell. Biol. 22 (15): 5479–91. doi:10.1128/MCB.22.15.5479-5491.2002. PMC 133950. PMID 12101241.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Han A, Saijo K, Mecklenbräuker I; et al. (2003). "Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival.". Immunity 19 (4): 621–32. doi:10.1016/S1074-7613(03)00275-9. PMID 14563325.
- Allam A, Niiro H, Clark EA, Marshall AJ (2004). "The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism.". J. Biol. Chem. 279 (38): 39775–82. doi:10.1074/jbc.M403367200. PMID 15247305.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Niiro H, Allam A, Stoddart A; et al. (2004). "The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization.". J. Immunol. 173 (9): 5601–9. doi:10.4049/jimmunol.173.9.5601. PMID 15494510.
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