Combretastatin A-4 phosphate
Systematic (IUPAC) name | |
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Phosphoric acid mono-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenyl} ester | |
Identifiers | |
PubChem | CID 5351387 |
ChemSpider | 4508406 |
Synonyms | CA4P; CA4PD; fosbretabulin; fosbretabulin disodium |
Chemical data | |
Formula | C18H21O8P |
Molar mass | 396.32 g/mol (exact mass : 396.097404) |
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- For more information about this drug and its actions, see combretastatin.
Combretastatin A-4 phosphate (fosbretabulin, and its salt fosbretabulin disodium) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. It is a derivative of combretastatin.
Combretastatin A-4 phosphate is a prodrug. In vivo, it is dephosphorylated to its active metabolite, combretastatin A-4.[1]
References
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