Clofoctol

Clofoctol
Systematic (IUPAC) name


2-[(2,4-dichlorophenyl)methyl]- 4-(2,4,4-trimethylpentan-2-yl)phenol
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Rectal (suppository)^[1]
Pharmacokinetic data
Bioavailability	98%^[1]
Metabolism	Hepatic glucuronidation^[1]
Excretion	Biliary^[1]
Identifiers
CAS Number	37693-01-9^Y
ATC code	J01XX03
PubChem	CID 2799
ChemSpider	2697^Y
UNII	704083NI0R^Y
KEGG	D07244^Y
ChEMBL	CHEMBL1476605
Chemical data
Formula	C₂₁H₂₆Cl₂O
Molar mass	365.336 g/mol
SMILES Clc1cc(Cl)ccc1Cc2cc(ccc2O)C(C)(C)CC(C)(C)C
InChI InChI=1S/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3^Y Key:HQVZOORKDNCGCK-UHFFFAOYSA-N^Y
(verify)

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.^[1] It is marketed in France under the trade name Octoplus and in Italy as Gramplus.

It is only functional against Gram-positive bacteria.^[2]

It penetrates into human lung tissue.^[3]

References

1 2 3 4 5 "Gramplus" (in Italian). Studio Medico Torrino. July 25, 2007. Retrieved 2007-08-10.
↑ Combe J, Simonnet F, Yablonsky F, Simonnet G (1980). "[Clofoctol binding by the bacteria (author's transl)]". J Pharmacol (in French) 11 (4): 411–25. PMID 6782374.
↑ Danesi R, Gasperini M, Senesi S, Freer G, Angeletti CA, Del Tacca M (1988). "A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay". Drugs Exp Clin Res 14 (1): 39–43. PMID 3391105.

Antibacterials: others (J01X)

Other/ungrouped	bornane: Xibornol cresol: Clofoctol polyamine: Methenamine alpha hydroxy acid: Mandelic acid nitroquinoline: Nitroxoline pyran/fatty acid: Isoleucine-tRNA ligase inhibitors (Mupirocin)

This article is issued from Wikipedia - version of the Friday, July 31, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.