Circular RNA (circRNA) databases and resources

Circular RNAs (circRNAs) refer to a class of circular RNA molecules found across all kingdoms of life.[1][2][3] Studies in 2013 have suggested that circRNAs play important regulatory roles in miRNA activity. Researchers found that CDR1as circRNA acts as a miR-7 super-sponge that contains about 70 target sites from the same miR-7 at the same transcript.[4][5] The other testis-specificcircRNA, sex-determining region Y (Sry), also was found as a miR-138 sponge.[6] About-mentioned examples suggesting that miRNA sponge effects achieved by circRNA formation may be a general phenomenon. As miR-7 modulates the expression of several oncogenes, ciRS-7/miR-7 interactions may play an important roles in cancer-related pathways.[7]

This Circular RNA (circRNA) databases and resources is a compilation of databases and web portals and servers used for circRNAs.

Name Description type Link References
circRNABase circRNABase is designed for decoding miRNA-circRNA interaction networks from thousands of circRNAs and 108 CLIP-Seq (HITS-CLIP, PAR-CLIP, iCLIP, CLASH) datasets. database website [8]
circBase circBase explore public circRNA datasets and download the custom python scripts needed to discover circRNAs in your own (ribominus) RNA-seq data. database website [9]
Circ2Traits Circ2Traits a comprehensive database for circular RNA potentially associated with disease and traits. databasedatabase [10]

References

  1. ↑ Memczak, S; Jens, M; Elefsinioti, A; Torti, F; Krueger, J; Rybak, A; Maier, L; Mackowiak, SD; Gregersen, LH; Munschauer, M; Loewer, A; Ziebold, U; Landthaler, M; Kocks, C; le Noble, F; Rajewsky, N (Mar 21, 2013). "Circular RNAs are a large class of animal RNAs with regulatory potency". Nature 495 (7441): 333–8. Bibcode:2013Natur.495..333M. doi:10.1038/nature11928. PMID 23446348.
  2. ↑ Hansen, TB; Jensen, TI; Clausen, BH; Bramsen, JB; Finsen, B; Damgaard, CK; Kjems, J (Mar 21, 2013). "Natural RNA circles function as efficient microRNA sponges.". Nature 495 (7441): 384–8. Bibcode:2013Natur.495..384H. doi:10.1038/nature11993. PMID 23446346.
  3. ↑ Kosik, KS (Mar 21, 2013). "Molecular biology: Circles reshape the RNA world.". Nature 495 (7441): 322–4. Bibcode:2013Natur.495..322K. doi:10.1038/nature11956. PMID 23446351.
  4. ↑ Memczak, S; Jens, M; Elefsinioti, A; Torti, F; Krueger, J; Rybak, A; Maier, L; Mackowiak, SD; Gregersen, LH; Munschauer, M; Loewer, A; Ziebold, U; Landthaler, M; Kocks, C; le Noble, F; Rajewsky, N (Mar 21, 2013). "Circular RNAs are a large class of animal RNAs with regulatory potency". Nature 495 (7441): 333–8. Bibcode:2013Natur.495..333M. doi:10.1038/nature11928. PMID 23446348.
  5. ↑ Hansen, TB; Jensen, TI; Clausen, BH; Bramsen, JB; Finsen, B; Damgaard, CK; Kjems, J (Mar 21, 2013). "Natural RNA circles function as efficient microRNA sponges.". Nature 495 (7441): 384–8. Bibcode:2013Natur.495..384H. doi:10.1038/nature11993. PMID 23446346.
  6. ↑ Hansen, TB; Jensen, TI; Clausen, BH; Bramsen, JB; Finsen, B; Damgaard, CK; Kjems, J (Mar 21, 2013). "Natural RNA circles function as efficient microRNA sponges.". Nature 495 (7441): 384–8. Bibcode:2013Natur.495..384H. doi:10.1038/nature11993. PMID 23446346.
  7. ↑ Hansen, TB; Kjems, J; Damgaard, CK (Sep 15, 2013). "Circular RNA and miR-7 in Cancer.". Cancer Research 73 (18): 5609–12. doi:10.1158/0008-5472.CAN-13-1568. PMID 24014594.
  8. ↑ Li, JH; Liu, S; Zhou, H; Qu, LH; Yang, JH (Jan 1, 2014). "starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.". Nucleic Acids Research 42 (1): D92–7. doi:10.1093/nar/gkt1248. PMID 24297251.
  9. ↑ Memczak, S; Jens, M; Elefsinioti, A; Torti, F; Krueger, J; Rybak, A; Maier, L; Mackowiak, SD; Gregersen, LH; Munschauer, M; Loewer, A; Ziebold, U; Landthaler, M; Kocks, C; le Noble, F; Rajewsky, N (Mar 21, 2013). "Circular RNAs are a large class of animal RNAs with regulatory potency". Nature 495 (7441): 333–8. Bibcode:2013Natur.495..333M. doi:10.1038/nature11928. PMID 23446348.
  10. ↑ Ghosal, S; Das, S; Sen, R; Basak, P; Chakrabarti, J (2013). "Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits.". Frontiers in Genetics 4: 283. doi:10.3389/fgene.2013.00283. PMC 3857533. PMID 24339831.

circbase.org original paper [1]

External links

  1. ↑ RNA. 2014 Nov;20(11):1666-70. doi: 10.1261/rna.043687.113. Epub 2014 Sep 18. circBase: a database for circular RNAs. Glažar P1, Papavasileiou P1, Rajewsky N2.
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