Meclofenoxate

Meclofenoxate
Systematic (IUPAC) name
2-Dimethylaminoethyl (4-chlorophenoxy)acetate
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
CAS Number 51-68-3 YesY
ATC code N06BX01
PubChem CID 4039
ChemSpider 3899 N
UNII C76QQ2I0RG YesY
KEGG D00993 YesY
Chemical data
Formula C12H16ClNO3
Molar mass 257.713
 NYesY (what is this?)  (verify)

Meclofenoxate (Lucidril), also known as centrophenoxine, is a cholinergic drug used to treat the symptoms of senile dementia and Alzheimer's disease. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). DMAE is a natural substance, found especially in fish. pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.

In elderly patients, it has been clinically shown to improve memory, have a mentally stimulating effect, and improve general cognition.[1] Meclofenoxate also increases cellular membrane phospholipids.

Side effects and contraindications

Meclofenoxate is generally considered safe. However possible side effects may include nausea or mild dizziness. People with severely high blood pressure or convulsive disorders such as epilepsy should avoid meclofenoxate.[2] Large doses may cause tight jaw clenching.

See also

References

  1. ↑ Marcer, D; Hopkins, SM (1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and ageing 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662.
  2. ↑ Centrophenoxine Page @ The American Academy of Anti-Aging Medicine Archived May 1, 2008 at the Wayback Machine


This article is issued from Wikipedia - version of the Sunday, January 10, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.