Centre for Magnetic Resonance Investigations

The front entrance to the Kingston upon Hull Centre for Magnetic Resonance Investigations.

The Kingston Upon Hull Centre for Magnetic Resonance Investigations (CMRI), which opened in 1992, is a magnetic resonance imaging centre located in the city of Kingston upon Hull (Hull) in the East Riding of Yorkshire, England, UK. It is situated in the grounds of the Hull Royal Infirmary hospital in the centre of the city.

The centre carries out both cancer research studies, under the auspices of the University of Hull, and clinical scanning, under the auspices of the local NHS trust, Hull and East Yorkshire Hospitals.

The centre currently has three MRI scanners; two 1.5 tesla scanners owned by the NHS (a Philips Intera and a GE Signa) and a state-of-the art 3.0 tesla MR 750 GE Signa scanner owned by the University which was installed in January 2009 (one of the first 3.0 tesla whole-body capable systems in Europe).

The three MRI scanners at the centre; (from left to right) a 1.5 tesla GE Signa, a 1.5 tesla Philips Intera and a 3.0 tesla GE Signa.

Research activities

The medical research is carried out under the Directorship of Professor Lindsay W. Turnbull, and is devoted to the application of magnetic resonance imaging and magnetic resonance spectroscopy techniques to the study of cancer.

Current research projects include investigations of cancer of the breast, prostate and cervix. Previous studies have involved investigations of cancer of the brain.

MRI techniques employed include dynamic contrast-enhanced MRI (DCE-MRI), diffusion-weighted MRI, functional MRI (fMRI, brain activation mapping), image textural analysis, proton spectroscopy and phosphorus spectroscopy.

Funding

The research is wholly funded by the charity Yorkshire Cancer Research.

Research staff

Scientific Director: Professor Lindsay W. Turnbull, M.D., F.R.C.R. (Radiologist)
Medical physicist: Peter Gibbs, Ph.D
Biochemist: Martin Lowry, D.Phil.
Research scientist: Martin D. Pickles, Ph.D.
Research Radiographers: Julie Pounder(Superintendent Radiographer); Daniel Siddons, Ph.D.
Ph.D. students: Lawrence Kenning, Nina Louise Purvis, Michael Fox

Recent publications

1. Liney, GP; Bernard, CP; Manton, DJ; et al. Age, gender, and skeletal variation in bone marrow composition: A preliminary study at 3.0 Tesla. JOURNAL OF MAGNETIC RESONANCE IMAGING, 26 (3): 787-793 September 2007

2. Bernard, CP; Liney, GP; Manton, DJ; et al. Bone marrow quantification using 3.0 tesla magnetic resonance imaging. JOURNAL OF BONE AND MINERAL RESEARCH, 22 (7): 1140-1140 July 2007

3. Sreenivas, A; Lowry, M; Gibbs, P; et al. A simple solution for reducing artefacts due to conductive and dielectric effects in clinical magnetic resonance imaging at 3 T. EUROPEAN JOURNAL OF RADIOLOGY, 62 (1): 143-146 April 2007

4. Pickles, MD; Gibbs, P; Lowry, M; et al. Diffusion changes precede size reduction in neoadjuvant treatment of breast cancer. MAGNETIC RESONANCE IMAGING, 24 (7): 843-847 September 2006

5. Liney, GP; Sreenivas, M; Gibbs, P; et al. Breast lesion analysis of shape technique: Semiautomated vs. manual morphological description. JOURNAL OF MAGNETIC RESONANCE IMAGING, 23 (4): 493-498 April 2006

6. Kneeshaw, PJ; Lowry, M; Manton, D; et al. Differentiation of benign from malignant breast disease associated with screening detected microcalcifications using dynamic contrast enhanced magnetic resonance imaging. BREAST, 15 (1): 29-38 February 2006

7. Pickles, MD; Gibbs, P; Sreenivas, M; et al. Diffusion-weighted imaging of normal and malignant prostate tissue at 3.0 T. JOURNAL OF MAGNETIC RESONANCE IMAGING, 23 (2): 130-134 February 2006

8. Gibbs, P; Pickles, MD; Turnbull, LW Diffusion imaging of the prostate at 3.0 tesla. INVESTIGATIVE RADIOLOGY, 41 (2): 185-188 February 2006

9. Manton, DJ; Chaturvedi, A; Hubbard, A; et al. Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy. BRITISH JOURNAL OF CANCER, 94 (3): 427-435 FEB 13 2006

10. Manton, DJ; Chaturvedi, A; Hubbard, A; et al. Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy. (vol 94, pg 1554, 2006) BRITISH JOURNAL OF CANCER, 94 (10): 1554-1554 MAY 22 2006

11. Pickles, MD; Lowry, M; Manton, DJ; et al. Role of dynamic contrast enhanced MRI in monitoring early response of locally advanced breast cancer to neoadjuvant chemotherapy. BREAST CANCER RESEARCH AND TREATMENT, 91 (1): 1-10 May 2005

12. Balan, P; Turnbull, LW Dynamic contrast enhanced magnetic resonance imaging and magnetic resonance spectroscopy in diabetic mastopathy. BREAST, 14 (1): 68-70 February 2005

References

External links

The University of Hull research department: http://www.hull.ac.uk/mri
The NHS MRI Department: http://www.hey.nhs.uk/mri/Default.asp
Hull and East Yorkshire Hospitals NHS Trust: http://www.hull.nhs.uk/

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