Caspase-10

Caspase-10
Identifiers
EC number 3.4.22.63
CAS number 189088-85-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Caspase-10 (EC 3.4.22.63, FLICE2, Mch4, CASP-10, ICE-like apoptotic protease 4, apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1beta-converting enzyme 2) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly

Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62).

References

  1. ↑ Chang, H.Y. and Yang, X. (2000). "Proteases for cell suicide: functions and regulation of caspases". Microbiol. Mol. Biol. Rev. 64: 821–846. doi:10.1128/mmbr.64.4.821-846.2000. PMID 11104820.
  2. ↑ Fischer, U., Stroh, C. and Schulze-Osthoff, K. (2006). "Unique and overlapping substrate specificities of caspase-8 and caspase-10". Oncogene 25: 152–159. doi:10.1038/sj.onc.1209015. PMID 16186808.
  3. ↑ Shikama, Y., Yamada, M. and Miyashita, T. (2003). "Caspase-8 and caspase-10 activate NF-κB through RIP, NIK and IKKα kinases". Eur. J. Immunol. 33: 1998–2006. doi:10.1002/eji.200324013. PMID 12884866.
  4. ↑ Boatright, K.M., Deis, C., Denault, J.B., Sutherlin, D.P. and Salvesen, G.S. (2004). "Activation of caspases-8 and -10 by FLIPL". Biochem. J. 382: 651–657. doi:10.1042/bj20040809. PMID 15209560.

External links

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