Carboxypeptidase U
Carboxypeptidase U (EC 3.4.17.20, arginine carboxypeptidase, carboxypeptidase R, plasma carboxypeptidase B, thrombin-activatable fibrinolysis inhibitor) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Release of C-terminal Arg and Lys from a polypeptide
Pro-carboxypeptidase U in (human) plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
See also
References
- ↑ Eaton, D.L., Malloy, B.E., Tsai, S.P., Henzel, W. and Drayna, D. (1991). "Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma". J. Biol. Chem. 266: 21833–21838. PMID 1939207.
- ↑ Shinohara, T., Sakurada, C., Suzuki, T., Takeuchi, O., Campbell, W., Ikeda, S., Okada, N. and Okada, H. (1994). "Pro-carboxypeptidase R cleaves bradykinin following activation". Int. Arch. Allergy Immunol. 103: 400–404. doi:10.1159/000236661. PMID 8130654.
- ↑ Wang, W., Hendriks, D.F. and Scharpé, S. (1994). "Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen". J. Biol. Chem. 269: 15937–15944. PMID 8195249.
- ↑ Tan, A.K. and Eaton, D.L. (1995). "Activation and characterization of procarboxypeptidase B from human plasma". Biochemistry 34: 5811–5816. doi:10.1021/bi00017a012. PMID 7727441.
- ↑ Broze, G.J., Jr. and Higuchi, D.A. (1996). "Coagulation-dependent inhibition of fibrinolysis: Role of carboxypeptidase U and the premature lysis of clots from hemophilic plasma". Blood 88: 3815–3823. PMID 8916945.
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