Cabot rings

Cabot rings are thin, red-violet staining, threadlike strands in the shape of a loop or figure-8 that are found on rare occasions in red blood cells (erythrocytes). They are believed to be microtubules that are remnants from a mitotic spindle, and their presence indicates an abnormality in the production of red blood cells.^[1]

Cytologic appearance

Cabot rings appear as ring, figure-8 or loop-shaped structures on microscopy. Cabot rings stain red or purple with Wright's stain.

Associated conditions

Cabot rings have been observed in a handful of cases in patients with pernicious anemia, lead poisoning, certain other disorders of red blood cell production (erythropoiesis).^[1]

History

They were first described in 1903 by American physician, Richard Clarke Cabot (1868-1939).

References

1 2 McPherson, Richard A; MR Pincus. Henry's clinical diagnosis and management by laboratory methods (22nd ed.). Philadelphia, PA: Elsevier/Saunders. p. 526. ISBN 978-1437709742.

External links

Microscopic Photo of Cabot Rings

Eponymous medical signs for hematology

Inclusion bodies	Red blood cell Cabot rings Howell–Jolly body Pappenheimer bodies Heinz body Neutrophil Döhle bodies Plasma cell Russell bodies Myeloblast Auer rod Histiocyte Birbeck granules

Tests	Apt test Coombs test

Other	Arneth count Mentzer index Virchow's triad Anaemia Pagophagia

Abnormal clinical and laboratory findings for blood tests (R70–R79, 790)

Red blood cells

Size	Anisocytosis Macrocyte Microcyte

Shape	Poikilocytosis membrane abnormalities: Acanthocyte Codocyte Ovalocyte Spherocyte Dacrocyte Echinocyte Schistocyte Degmacyte Drepanocyte Stomatocyte Knizocyte

Hemoglobinization	Anisochromia Hypochromia

Inclusion bodies	Developmental Howell–Jolly body Basophilic stippling Pappenheimer bodies Cabot rings Hemoglobin precipitation Heinz body

Other	Rouleaux Reticulocyte Elevated ESR

Lymphocytes

Small molecules

Blood sugar	Hypoglycemia Hyperglycemia Prediabetes Impaired fasting glucose Impaired glucose tolerance Oxyhyperglycemia

Nitrogenous	Azotemia Hyperuricemia Hypouricemia

Proteins

LFT	Elevated transaminases Elevated ALP Hypoproteinemia Hypoalbuminemia

Other	Elevated cardiac markers Elevated alpha-fetoprotein

Minerals

Iron overload disorder

Pathogens/sepsis

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