CTDSP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

PDB rendering based on 1t9z.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1T9Z, 1TA0, 2GHQ, 2GHT, 3L0B, 3L0C, 3L0Y, 3PGL

Identifiers

Symbols

CTDSP1 ; NIF3; NLI-IF; NLIIF; SCP1

External IDs

OMIM: 605323 MGI: 2654470 HomoloGene: 100834 ChEMBL: 1795098 GeneCards: CTDSP1 Gene

EC number

3.1.3.16

Gene ontology
Molecular function	• protein binding • CTD phosphatase activity • metal ion binding
Cellular component	• nucleus • extracellular exosome
Biological process	• negative regulation of protein phosphorylation • regulation of transcription from RNA polymerase II promoter • protein dephosphorylation • negative regulation of neuron differentiation • negative regulation of G1/S transition of mitotic cell cycle
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
218.4 – 218.41 Mb

Chr 1:
74.39 – 74.4 Mb

PubMed search

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene.^[1]^[2]^[3]

Interactions

CTDSP1 has been shown to interact with SNAI1.^[4]

References

↑ Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility". J Hum Genet 47 (3): 140–5. doi:10.1007/s100380200016. PMID 11950066.
↑ Yeo M, Lin PS, Dahmus ME, Gill GN (Jul 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". J Biol Chem 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
↑ "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1".
↑ Wu, Yadi; Evers B Mark; Zhou Binhua P (Jan 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". J. Biol. Chem. (United States) 284 (1): 640–8. doi:10.1074/jbc.M806916200. ISSN 0021-9258. PMC 2610500. PMID 19004823.

Marquet S, Lepage P, Hudson TJ; et al. (2000). "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35.". Mamm. Genome 11 (9): 755–62. doi:10.1007/s003350010151. PMID 10967134.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fernandes AO, Campagnoni CW, Kampf K; et al. (2004). "Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system.". J. Neurosci. Res. 75 (4): 461–71. doi:10.1002/jnr.10882. PMID 14743429.
Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yeo M, Lee SK, Lee B; et al. (2005). "Small CTD phosphatases function in silencing neuronal gene expression.". Science 307 (5709): 596–600. doi:10.1126/science.1100801. PMID 15681389.
Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Sapkota G, Knockaert M, Alarcón C; et al. (2007). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.". J. Biol. Chem. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.

PDB gallery

1t9z: Three-dimensional structure of a RNA-polymerase II binding protein.

1ta0: Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand.

2ghq: CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II

2ght: CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA polymerase II

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CTDSP1

Interactions

References

Further reading