CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

PDB rendering based on 1onv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CTDP1 ; CCFDN; FCP1
External IDs OMIM: 604927 MGI: 1926953 HomoloGene: 31254 GeneCards: CTDP1 Gene
EC number 3.1.3.16
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9150 67655
Ensembl ENSG00000060069 ENSMUSG00000033323
UniProt Q9Y5B0 Q7TSG2
RefSeq (mRNA) NM_001202504 NM_026295
RefSeq (protein) NP_001189433 NP_080571
Location (UCSC) Chr 18:
79.68 – 79.76 Mb
Chr 18:
80.41 – 80.47 Mb
PubMed search

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.[1][2][3]

This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.[3]

Interactions

CTDP1 has been shown to interact with WD repeat-containing protein 77,[4] GTF2F1[2] and POLR2A.[5]

References

  1. Archambault J, Chambers RS, Kobor MS, Ho Y, Cartier M, Bolotin D, Andrews B, Kane CM, Greenblatt J (Feb 1998). "An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A 94 (26): 14300–5. doi:10.1073/pnas.94.26.14300. PMC 24951. PMID 9405607.
  2. 1 2 Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (Nov 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J Biol Chem 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.
  3. 1 2 "Entrez Gene: CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1".
  4. Licciardo, Paolo; Amente Stefano; Ruggiero Luca; Monti Maria; Pucci Piero; Lania Luigi; Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. (England) 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496.
  5. Scully, R; Anderson S F; Chao D M; Wei W; Ye L; Young R A; Livingston D M; Parvin J D (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. ISSN 0027-8424. PMC 20825. PMID 9159119.

Further reading


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