CSNK1D

Casein kinase 1, delta
PDB rendering based on 1cki.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3UYS​, 3UYT​, 3UZP​, 4HGT​, 4HNF​, 4KB8​, 4KBA​, 4KBC​, 4KBK​, 4TW9​, 4TWC​
Identifiers
Symbols	CSNK1D ; ASPS; CKIdelta; FASPS2; HCKID
External IDs	OMIM: 600864 MGI: 1355272 HomoloGene: 74841 ChEMBL: 2828 GeneCards: CSNK1D Gene
EC number	2.7.11.1, 2.7.11.26
Gene ontology Molecular function • glycoprotein binding • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • peptide binding • tau-protein kinase activity • phosphoprotein binding Cellular component • nucleus • cytoplasm • Golgi apparatus • centrosome • spindle • cytosol • spindle microtubule • plasma membrane • perinuclear region of cytoplasm Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • positive regulation of protein phosphorylation • DNA repair • protein phosphorylation • endocytosis • organelle organization • microtubule nucleation • Golgi organization • signal transduction • regulation of cell shape • Wnt signaling pathway • peptidyl-serine phosphorylation • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • circadian regulation of gene expression • protein localization to Golgi apparatus • nonmotile primary cilium assembly • regulation of circadian rhythm • spindle assembly • protein localization to cilium • protein localization to centrosome • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1453	104318
Ensembl	ENSG00000141551	ENSMUSG00000025162
UniProt	P48730	Q9DC28
RefSeq (mRNA)	NM_001893	NM_027874
RefSeq (protein)	NP_001884	NP_082150
Location (UCSC)	Chr 17: 82.24 – 82.27 Mb	Chr 11: 120.96 – 120.99 Mb
PubMed search

The CSNK1D gene encodes the casein kinase I isoform delta enzyme in humans.^[1]

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for this gene.^[2]

Interactions

CSNK1D has been shown to interact with Gap junction protein, alpha 1.^[3]

References

Further reading

PDB gallery 1cki: RECOMBINANT CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317  1ckj: CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317 COMPLEX WITH BOUND TUNGSTATE