CRTC1
CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1, not to be confused with the unrelated target of rapamycin complex 1 (mTORC1)) is a protein that in humans is encoded by the CRTC1 gene.[1][2][3][4] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands.[5]
Clinical significance
Production of CRTC1 is blocked in Alzheimer's disease.[6]
See also
References
- ↑ Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (Jan 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nat Genet 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049.
- ↑ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Oct 2003). "TORCs: transducers of regulated CREB activity". Mol Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
- ↑ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proc Natl Acad Sci U S A 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
- ↑ "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1".
- ↑ Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers.
- ↑ Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA (2014). "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". J. Neurosci. 34 (17): 5776–87. doi:10.1523/JNEUROSCI.5288-13.2014. PMID 24760838.
Further reading
- Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity.". PNAS 104 (11): 4700–5. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
- Takemori H, Kajimura J, Okamoto M (2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain.". FEBS J. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Ishikawa K, Nagase T, Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
- Enlund F, Behboudi A, Andrén Y; et al. (2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.". Exp. Cell Res. 292 (1): 21–8. doi:10.1016/j.yexcr.2003.09.007. PMID 14720503.
- Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Screaton RA, Conkright MD, Katoh Y; et al. (2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.". Cell 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
- Bittinger MA, McWhinnie E, Meltzer J; et al. (2005). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins.". Curr. Biol. 14 (23): 2156–61. doi:10.1016/j.cub.2004.11.002. PMID 15589160.
- Behboudi A, Winnes M, Gorunova L; et al. (2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.". Genes Chromosomes Cancer 43 (2): 202–5. doi:10.1002/gcc.20168. PMID 15729701.
- Komiya T, Park Y, Modi S; et al. (2006). "Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation.". Oncogene 25 (45): 6128–32. doi:10.1038/sj.onc.1209627. PMID 16652146.
- Siu YT, Chin KT, Siu KL; et al. (2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats.". J. Virol. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMC 1489057. PMID 16809310.
- Katoh Y, Takemori H, Lin XZ; et al. (2006). "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.". FEBS J. 273 (12): 2730–48. doi:10.1111/j.1742-4658.2006.05291.x. PMID 16817901.
- Okabe M, Miyabe S, Nagatsuka H; et al. (2007). "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma.". Clin. Cancer Res. 12 (13): 3902–7. doi:10.1158/1078-0432.CCR-05-2376. PMID 16818685.
External links
- CRTC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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