CR6261

CR6261
Monoclonal antibody
Type ?
Source Human
Target Influenza A hemagglutinin
Clinical data
Pregnancy
category
  • N/A
Legal status
  • Investigational (animal studies)
Identifiers
ATC code None
ChemSpider none
 NYesY (what is this?)  (verify)

CR6261 is a monoclonal antibody[1] that binds to a broad range of the influenza virus including the 1918 "Spanish flu" (SC1918/H1) and to a virus of the H5N1 class of avian influenza that jumped from chickens to a human in Vietnam in 2004 (Viet04/H5). In contrast to most antibodies generated by exposure to influenza, which can only neutralize a few strains from within a single virus subtype, CR6261 neutralizes numerous strains from multiple subtypes. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of hemagglutinin, the predominant protein on the surface of the influenza virus. Based upon the conservation of the amino acid sequence on this part of hemagglutinin, CR6261 is predicted to neutralize roughly 50% of all flu viruses. It was found by The Scripps Research Institute and the Dutch biopharmaceutical company, Crucell.

See also

References

  1. ↑ Friesen, R. H. E.; Koudstaal, W.; Koldijk, M. H.; Weverling, G. J.; Brakenhoff, J. P. J.; Lenting, P. J.; Stittelaar, K. J.; Osterhaus, A. D. M. E.; Kompier, R.; Goudsmit, J. (2010). Zhang, Linqi, ed. "New Class of Monoclonal Antibodies against Severe Influenza: Prophylactic and Therapeutic Efficacy in Ferrets". PLoS ONE 5 (2): e9106. doi:10.1371/journal.pone.0009106. PMC 2817000. PMID 20161706.
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