COX7A2L
| Cytochrome c oxidase subunit VIIa polypeptide 2 like | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | COX7A2L ; COX7AR; COX7RP; EB1; SIG81 | ||||||||||||
| External IDs | OMIM: 605771 MGI: 106015 HomoloGene: 3463 GeneCards: COX7A2L Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9167 | 20463 | |||||||||||
| Ensembl | ENSG00000115944 | ENSMUSG00000024248 | |||||||||||
| UniProt | O14548 | Q61387 | |||||||||||
| RefSeq (mRNA) | NM_004718 | NM_001159529 | |||||||||||
| RefSeq (protein) | NP_004709 | NP_001153001 | |||||||||||
| Location (UCSC) |
Chr 2: 42.33 – 42.43 Mb |
Chr 17: 83.5 – 83.51 Mb | |||||||||||
| PubMed search | |||||||||||||
Cytochrome c oxidase subunit 7A-related protein, mitochondrial is an enzyme that in humans is encoded by the COX7A2L gene.[1][2]
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.[2]
References
- ↑ Watanabe T, Inoue S, Hiroi H, Orimo A, Kawashima H, Muramatsu M (Jan 1998). "Isolation of estrogen-responsive genes with a CpG island library". Mol Cell Biol 18 (1): 442–9. PMC 121513. PMID 9418891.
- 1 2 "Entrez Gene: COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like".
Further reading
- Segade F, Hurlé B, Claudio E; et al. (1996). "Identification of an additional member of the cytochrome c oxidase subunit VIIa family of proteins.". J. Biol. Chem. 271 (21): 12343–9. doi:10.1074/jbc.271.21.12343. PMID 8647836.
- Schmidt TR, Goodman M, Grossman LI (1999). "Molecular evolution of the COX7A gene family in primates.". Mol. Biol. Evol. 16 (5): 619–26. doi:10.1093/oxfordjournals.molbev.a026144. PMID 10335655.
- Lee N, Daly MJ, Delmonte T; et al. (2001). "A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac-Saint-Jean cytochrome oxidase deficiency to 2p16.". Am. J. Hum. Genet. 68 (2): 397–409. doi:10.1086/318197. PMC 1235273. PMID 11156535.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Schmidt TR, Doan JW, Goodman M, Grossman LI (2004). "Retention of a duplicate gene through changes in subcellular targeting: an electron transport protein homologue localizes to the golgi.". J. Mol. Evol. 57 (2): 222–8. doi:10.1007/s00239-003-2468-8. PMID 14562965.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.