Collagen, type VIII, alpha 1
Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene.[1][2]
This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same isoform have been observed.[2]
References
Further reading
- Shuttleworth CA (1998). "Type VIII collagen.". Int. J. Biochem. Cell Biol. 29 (10): 1145–8. doi:10.1016/S1357-2725(97)00033-2. PMID 9438378.
- Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis.". Atherosclerosis 166 (1): 1–11. doi:10.1016/S0021-9150(01)00766-3. PMID 12482545.
- Illidge C, Kielty C, Shuttleworth A (1998). "The alpha1(VIII) and alpha2(VIII) chains of type VIII collagen can form stable homotrimeric molecules.". J. Biol. Chem. 273 (34): 22091–5. doi:10.1074/jbc.273.34.22091. PMID 9705353.
- Hou G, Mulholland D, Gronska MA, Bendeck MP (2000). "Type VIII collagen stimulates smooth muscle cell migration and matrix metalloproteinase synthesis after arterial injury.". Am. J. Pathol. 156 (2): 467–76. doi:10.1016/s0002-9440(10)64751-7. PMC 1850039. PMID 10666376.
- Leung EW, Rife L, Smith RE, Kay EP (2000). "Extracellular matrix components in retrocorneal fibrous membrane in comparison to corneal endothelium and Descemet's membrane.". Mol. Vis. 6: 15–23. PMID 10731515.
- de Vries CJ, van Achterberg TA, Horrevoets AJ; et al. (2000). "Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes.". J. Biol. Chem. 275 (31): 23939–47. doi:10.1074/jbc.M910099199. PMID 10823842.
- Biswas S, Munier FL, Yardley J; et al. (2002). "Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy.". Hum. Mol. Genet. 10 (21): 2415–23. doi:10.1093/hmg/10.21.2415. PMID 11689488.
- Wistow G, Bernstein SL, Wyatt MK; et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205–20. PMID 12107410.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kvansakul M, Bogin O, Hohenester E, Yayon A (2004). "Crystal structure of the collagen alpha1(VIII) NC1 trimer.". Matrix Biol. 22 (2): 145–52. doi:10.1016/S0945-053X(02)00119-1. PMID 12782141.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Aldave AJ, Rayner SA, Salem AK; et al. (2006). "No pathogenic mutations identified in the COL8A1 and COL8A2 genes in familial Fuchs corneal dystrophy.". Invest. Ophthalmol. Vis. Sci. 47 (9): 3787–90. doi:10.1167/iovs.05-1635. PMID 16936088.
- Aldave AJ, Bourla N, Yellore VS; et al. (2007). "Keratoconus is not associated with mutations in COL8A1 and COL8A2.". Cornea 26 (8): 963–5. doi:10.1097/ICO.0b013e31811dfaf7. PMID 17721297.
PDB gallery |
|---|
| | 1o91: CRYSTAL STRUCTURE OF A COLLAGEN VIII NC1 DOMAIN TRIMER |
|
|
|
