CLEC1B
| C-type lectin domain family 1, member B | |||||||||||||
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PDB rendering based on 2c6u. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CLEC1B ; 1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721 | ||||||||||||
| External IDs | OMIM: 606783 MGI: 1913287 HomoloGene: 49468 GeneCards: CLEC1B Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51266 | 56760 | |||||||||||
| Ensembl | ENSG00000165682 | ENSMUSG00000030159 | |||||||||||
| UniProt | Q9P126 | Q9JL99 | |||||||||||
| RefSeq (mRNA) | NM_001099431 | NM_001204239 | |||||||||||
| RefSeq (protein) | NP_001092901 | NP_001191168 | |||||||||||
| Location (UCSC) |
Chr 12: 9.99 – 10.01 Mb |
Chr 6: 129.4 – 129.41 Mb | |||||||||||
| PubMed search | |||||||||||||
C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.[1][2][3]
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM][3]
References
- ↑ Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229.
- ↑ Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369.
- 1 2 "Entrez Gene: CLEC1B C-type lectin domain family 1, member B".
Further reading
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Suzuki-Inoue K, Fuller GL, García A; et al. (2006). "A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2". Blood 107 (2): 542–9. doi:10.1182/blood-2005-05-1994. PMID 16174766.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Watson AA, O'Callaghan CA (2006). "Crystallization and X-ray diffraction analysis of human CLEC-2". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 12): 1094–6. doi:10.1107/S1744309105037991. PMC 1978148. PMID 16511244.
- Scherer SE, Muzny DM, Buhay CJ; et al. (2006). "The finished DNA sequence of human chromosome 12". Nature 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.
- Chaipan C, Soilleux EJ, Simpson P; et al. (2006). "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets". J. Virol. 80 (18): 8951–60. doi:10.1128/JVI.00136-06. PMC 1563896. PMID 16940507.
- Watson AA, Brown J, Harlos K; et al. (2007). "The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2". J. Biol. Chem. 282 (5): 3165–72. doi:10.1074/jbc.M610383200. PMID 17132623.
- Suzuki-Inoue K, Kato Y, Inoue O; et al. (2007). "Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells". J. Biol. Chem. 282 (36): 25993–6001. doi:10.1074/jbc.M702327200. PMID 17616532.
- Watson AA, Eble JA, O'Callaghan CA (2008). "Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2". Prot. Sci. 17 (9): 1611–6. doi:10.1110/ps.035568.108. PMC 2525532. PMID 18583525.
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