CHKB (gene)

Choline kinase beta

PDB rendering based on 2ig7.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2IG7, 3FEG, 3LQ3

Identifiers

Symbols

CHKB ; CHETK; CHKL; CK; CKB; CKEKB; EK; EKB; MDCMC

External IDs

OMIM: 612395 MGI: 1328313 HomoloGene: 88718 GeneCards: CHKB Gene

EC number

2.7.1.32, 2.7.1.82

Gene ontology
Molecular function	• choline kinase activity • ethanolamine kinase activity • ATP binding
Cellular component	• cytosol
Biological process	• phospholipid metabolic process • phosphatidylethanolamine biosynthetic process • phosphatidylcholine biosynthetic process • CDP-choline pathway • phosphorylation • small molecule metabolic process • glycerophospholipid biosynthetic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
50.58 – 50.6 Mb

Chr 15:
89.42 – 89.43 Mb

PubMed search

Choline kinase beta is a protein encoded by the CHKB gene.^[1]^[2] This gene is found on chromosome 22 in humans.^[3]

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.^[3]

References

↑ Yamazaki N, Yamanaka Y, Hashimoto Y, Shinohara Y, Shima A, Terada H (June 1997). "Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I". FEBS Lett. 409 (3): 401–6. doi:10.1016/S0014-5793(97)00561-9. PMID 9224698.
↑ Aoyama C, Liao H, Ishidate K (May 2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog. Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397.
1 2 "Entrez Gene: CHKB choline kinase beta".

Aoyama C, Liao H, Ishidate K (2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog. Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397.
Ishidate K (1997). "Choline/ethanolamine kinase from mammalian tissues". Biochim. Biophys. Acta 1348 (1-2): 70–8. doi:10.1016/s0005-2760(97)00118-5. PMID 9370318.
Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hirosawa M, Nagase T, Murahashi Y; et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
Yamazaki N, Shinohara Y, Kajimoto K; et al. (2000). "Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I". J. Biol. Chem. 275 (41): 31739–46. doi:10.1074/jbc.M006322200. PMID 10918069.
Aoyama C, Yamazaki N, Terada H, Ishidate K (2000). "Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta". J. Lipid Res. 41 (3): 452–64. PMID 10706593.
Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
Aoyama C, Nakashima K, Matsui M, Ishidate K (1998). "Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase". Biochim. Biophys. Acta 1390 (1): 1–7. doi:10.1016/s0005-2760(97)00177-x. PMID 9487136.
Yamazaki N, Yamanaka Y, Hashimoto Y; et al. (1997). "Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I". FEBS Lett. 409 (3): 401–6. doi:10.1016/S0014-5793(97)00561-9. PMID 9224698.

PDB gallery

2ig7: Crystal structure of Human Choline Kinase B

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CHKB (gene)

References

Further reading