CHD5

Chromodomain helicase DNA binding protein 5

PDB rendering based on 1mm2.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1mm2

Identifiers

Symbols

CHD5 ; CHD-5

External IDs

OMIM: 610771 MGI: 3036258 HomoloGene: 56712 GeneCards: CHD5 Gene

EC number

3.6.4.12

Gene ontology
Molecular function	• DNA binding • chromatin binding • ATP binding • ATP-dependent helicase activity • zinc ion binding • H3K27me3 modified histone binding
Cellular component	• heterochromatin • nucleus • membrane • NuRD complex
Biological process	• transcription from RNA polymerase II promoter • negative regulation of cell proliferation • cerebral cortex neuron differentiation • spermatogenesis, exchange of chromosomal proteins • histone H4 acetylation • regulation of transcription involved in cell fate commitment • histone H3-K27 trimethylation • positive regulation of signal transduction by p53 class mediator
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
152.34 – 152.39 Mb

PubMed search

Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene.^[1]^[2]^[3]

References

↑ Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID 11889561.
↑ Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene 22 (7): 1002–11. doi:10.1038/sj.onc.1206211. PMID 12592387.
↑ "Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Bagchi A, Papazoglu C, Wu Y, et al. (2007). "CHD5 is a tumor suppressor at human 1p36". Cell 128 (3): 459–75. doi:10.1016/j.cell.2006.11.052. PMID 17289567.

PDB gallery

1mm2: Solution structure of the 2nd PHD domain from Mi2b

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CHD5

References

Further reading