CENTD1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

PDB rendering based on 1x40.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1X40, 2COD

Identifiers

Symbols

ARAP2 ; CENTD1; PARX

External IDs

OMIM: 606645 MGI: 2684416 HomoloGene: 9064 GeneCards: ARAP2 Gene

Gene ontology
Molecular function	• GTPase activator activity • phosphatidylinositol-3,4,5-trisphosphate binding • metal ion binding
Cellular component	• cytosol
Biological process	• small GTPase mediated signal transduction • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
35.95 – 36.24 Mb

Chr 5:
62.6 – 62.77 Mb

PubMed search

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.^[1]

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. This protein lacks the predicted catalytic arginine in the RHO-GAP domain and is therefore unlikely to have RHO-GAP activity. While the encoded protein does contain a sterile alpha motif (SAM) commonly found in some signaling molecules, the function of the protein has not been determined. Two transcript variants encoding different isoforms have been found for this gene.^[1]

References

1 2 "Entrez Gene: CENTD1 centaurin, delta 1".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Yoon HY, Miura K, Cuthbert EJ, et al. (2007). "ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP". J. Cell. Sci. 119 (Pt 22): 4650–4666. doi:10.1242/jcs.03237. PMID 17077126.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–731. doi:10.1038/nature03466. PMID 15815621.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Miura K, Jacques KM, Stauffer S, et al. (2002). "ARAP1: a point of convergence for Arf and Rho signaling". Mol. Cell 9 (1): 109–119. doi:10.1016/S1097-2765(02)00428-8. PMID 11804590.
Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–39. doi:10.1093/dnares/5.1.31. PMID 9628581.

PDB gallery

1x40: Solution structure of the SAM domain of human ARAP2

2cod: The deposition and citation title is: Solution structure of the N-terminal PH domain of ARAP2 protein from human

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CENTD1

References

Further reading