CDH8
| Cadherin 8, type 2 | |||||||||||||
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PDB rendering based on 1zxk. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CDH8 ; Nbla04261 | ||||||||||||
| External IDs | OMIM: 603008 MGI: 107434 HomoloGene: 55604 GeneCards: CDH8 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1006 | 12564 | |||||||||||
| Ensembl | ENSG00000150394 | ENSMUSG00000036510 | |||||||||||
| UniProt | P55286 | P97291 | |||||||||||
| RefSeq (mRNA) | NM_001796 | NM_001039154 | |||||||||||
| RefSeq (protein) | NP_001787 | NP_001034243 | |||||||||||
| Location (UCSC) |
Chr 16: 61.65 – 62.04 Mb |
Chr 8: 99.02 – 99.42 Mb | |||||||||||
| PubMed search | |||||||||||||
Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.[1][2][3]
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.[3]
References
- ↑ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
- ↑ Suzuki S, Sano K, Tanihara H (Aug 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
- 1 2 "Entrez Gene: CDH8 cadherin 8, type 2".
Further reading
- Tanihara H, Sano K, Heimark RL; et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin". Cell Adhes. Commun. 2 (1): 15–26. doi:10.3109/15419069409014199. PMID 7982033.
- Kido M, Obata S, Tanihara H; et al. (1998). "Molecular properties and chromosomal location of cadherin-8". Genomics 48 (2): 186–94. doi:10.1006/geno.1997.5152. PMID 9521872.
- Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
- Blaschke S, Mueller CA, Markovic-Lipkovski J; et al. (2002). "Expression of cadherin-8 in renal cell carcinoma and fetal kidney". Int. J. Cancer 101 (4): 327–34. doi:10.1002/ijc.10623. PMID 12209956.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
External links
- CDH8 human gene location in the UCSC Genome Browser.
- CDH8 human gene details in the UCSC Genome Browser.
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