T-cell surface glycoprotein CD3 epsilon chain

CD3e molecule, epsilon (CD3-TCR complex)

PDB rendering based on 1xiw.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1A81, 1SY6, 1XIW, 2ROL

Identifiers

Symbols

CD3E ; IMD18; T3E; TCRE

External IDs

OMIM: 186830 MGI: 88332 HomoloGene: 586 ChEMBL: 1975 GeneCards: CD3E Gene

Gene ontology
Molecular function	• transmembrane signaling receptor activity • receptor signaling protein activity • protein binding • SH3 domain binding • protein kinase binding • receptor signaling complex scaffold activity • T cell receptor binding • protein heterodimerization activity
Cellular component	• immunological synapse • intracellular • plasma membrane • integral component of plasma membrane • cell-cell junction • external side of plasma membrane • T cell receptor complex • alpha-beta T cell receptor complex
Biological process	• positive regulation of T cell anergy • protein complex assembly • cell surface receptor signaling pathway • transmembrane receptor protein tyrosine kinase signaling pathway • signal complex assembly • G-protein coupled receptor signaling pathway • response to nutrient • positive regulation of gene expression • negative regulation of gene expression • T cell costimulation • positive regulation of interferon-gamma production • positive regulation of interleukin-4 production • intracellular signal transduction • positive regulation of T cell proliferation • T cell activation • regulation of apoptotic process • negative thymic T cell selection • positive regulation of interleukin-2 biosynthetic process • negative regulation of smoothened signaling pathway • positive regulation of alpha-beta T cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • regulation of immune response • positive regulation of calcium-mediated signaling • T cell receptor signaling pathway • apoptotic signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

916

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
118.3 – 118.32 Mb

Chr 9:
45 – 45.01 Mb

PubMed search

CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.^[1]^[2]

Function

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.^[3]

Clinical significance

Defects in this gene cause severe immunodeficiency.^[4]^[5] This gene has also been linked to a susceptibility to type I diabetes in women.^[6]

Interactions

T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B,^[7] CD3EAP^[8] and NCK2.^[9]

References

↑ Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex". Nature 321 (6068): 431–4. doi:10.1038/321431a0. PMID 3012357.
↑ Clevers HC, Dunlap S, Wileman TE, Terhorst C (November 1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter". Proc. Natl. Acad. Sci. U.S.A. 85 (21): 8156–60. doi:10.1073/pnas.85.21.8156. PMC 282386. PMID 3267235.
↑ "Entrez Gene: CD3E CD3e molecule, epsilon (CD3-TCR complex)".
↑ Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B (January 1993). "Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency". Nat. Genet. 3 (1): 77–81. doi:10.1038/ng0193-77. PMID 8490660.
↑ de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F (November 2004). "Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3". J. Clin. Invest. 114 (10): 1512–7. doi:10.1172/JCI22588. PMC 525745. PMID 15546002.
↑ Wong S, Moore S, Orisio S, Millward A, Demaine AG (January 1991). "Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11". Clin. Exp. Immunol. 83 (1): 69–73. doi:10.1111/j.1365-2249.1991.tb05590.x. PMC 1535466. PMID 1671006.
↑ Nakano, H; Yamazaki T; Miyatake S; Nozaki N; Kikuchi A; Saito T (Mar 1996). "Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex". J. Biol. Chem. (UNITED STATES) 271 (11): 6483–9. doi:10.1074/jbc.271.11.6483. ISSN 0021-9258. PMID 8626450.
↑ Yamazaki, T; Hamano Y; Tashiro H; Itoh K; Nakano H; Miyatake S; Saito T (Jun 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". J. Biol. Chem. (UNITED STATES) 274 (26): 18173–80. doi:10.1074/jbc.274.26.18173. ISSN 0021-9258. PMID 10373416.
↑ Gil, Diana; Schamel Wolfgang W A, Montoya María, Sánchez-Madrid Francisco, Alarcón Balbino (Jun 2002). "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation". Cell (United States) 109 (7): 901–12. doi:10.1016/S0092-8674(02)00799-7. ISSN 0092-8674. PMID 12110186. Cite uses deprecated parameter |coauthors= (help)

Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference.". J. Cell. Physiol. 209 (3): 695–700. doi:10.1002/jcp.20817. PMID 17001685.
Thoenes G, Soudais C, le Deist F, et al. (1992). "Structural analysis of low TCR-CD3 complex expression in T cells of an immunodeficient patient.". J. Biol. Chem. 267 (1): 487–93. PMID 1370449.
Luzzati AL, Giacomini E, Giordani L, et al. (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope.". Immunol. Lett. 33 (3): 307–14. doi:10.1016/0165-2478(92)90078-3. PMID 1385321.
Lanier LL, Chang C, Spits H, Phillips JH (1992). "Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes.". J. Immunol. 149 (6): 1876–80. PMID 1387664.
Wong S, Moore S, Orisio S, et al. (1991). "Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11.". Clin. Exp. Immunol. 83 (1): 69–73. doi:10.1111/j.1365-2249.1991.tb05590.x. PMC 1535466. PMID 1671006.
Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.". Cell. Immunol. 137 (1): 1–13. doi:10.1016/0008-8749(91)90051-C. PMID 1832084.
Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
Luzzati AL, Pugliese O, Giacomini E, et al. (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV.". Folia Biol. (Praha) 36 (1): 71–7. PMID 2111780.
Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex.". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083.
van den Elsen P, Shepley BA, Cho M, Terhorst C (1985). "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein.". Nature 314 (6011): 542–4. doi:10.1038/314542a0. PMID 2859526.
Gold DP, Puck JM, Pettey CL, et al. (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex.". Nature 321 (6068): 431–4. doi:10.1038/321431a0. PMID 3012357.
Clevers HC, Dunlap S, Wileman TE, Terhorst C (1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter.". Proc. Natl. Acad. Sci. U.S.A. 85 (21): 8156–60. doi:10.1073/pnas.85.21.8156. PMC 282386. PMID 3267235.
Gold DP, Clevers H, Alarcon B, et al. (1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7649–53. doi:10.1073/pnas.84.21.7649. PMC 299357. PMID 3478717.
DeNofrio D, Radcliff G, Weinhold KJ, Denning SM (1996). "CD3 delta and epsilon gene expression in CD3-CD16+ natural killer cell clones derived from thymic precursors.". Hum. Immunol. 43 (4): 283–94. doi:10.1016/0198-8859(95)91034-U. PMID 7499176.
Kishimoto H, Kubo RT, Yorifuji H, et al. (1996). "Physical dissociation of the TCR-CD3 complex accompanies receptor ligation.". J. Exp. Med. 182 (6): 1997–2006. doi:10.1084/jem.182.6.1997. PMC 2192252. PMID 7500045.
Oravecz T, Norcross MA (1994). "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120.". AIDS Res. Hum. Retroviruses 9 (10): 945–55. doi:10.1089/aid.1993.9.945. PMID 7506554.
Beecher MS, Baiocchi RA, Linett ML, et al. (1994). "Expression of the zeta protein subunit in CD3- NK effectors derived from human thymus.". Cell. Immunol. 155 (2): 508–16. doi:10.1006/cimm.1994.1143. PMID 7514106.
Luzzati AL, Giacomini E, Giordani L, et al. (1994). "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex.". Cell. Immunol. 156 (2): 286–95. doi:10.1006/cimm.1994.1175. PMID 7517794.
Dianzani U, Bragardo M, Buonfiglio D, et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.". Eur. J. Immunol. 25 (5): 1306–11. doi:10.1002/eji.1830250526. PMID 7539755.
Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29).". Immunol. Lett. 44 (2-3): 97–103. doi:10.1016/0165-2478(94)00199-2. PMID 7541024.

PDB gallery

1xiw: Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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T-cell surface glycoprotein CD3 epsilon chain

Function

Clinical significance

Interactions

See also

References

Further reading