CD163

CD163 molecule
Identifiers
Symbols CD163 ; M130; MM130
External IDs OMIM: 605545 MGI: 2135946 HomoloGene: 128811 GeneCards: CD163 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9332 93671
Ensembl ENSG00000177575 ENSMUSG00000008845
UniProt Q86VB7 Q2VLH6
RefSeq (mRNA) NM_004244 NM_001170395
RefSeq (protein) NP_004235 NP_001163866
Location (UCSC) Chr 12:
7.47 – 7.5 Mb		 Chr 6:
124.3 – 124.33 Mb
PubMed search

CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene.[1] CD163 is the high affinity scavenger receptor for the hemoglobin-haptoglobin complex and in the absence of haptoglobin - with lower affinity - for hemoglobin alone.[2] It has also been shown to mark cells of monocyte/macrophage lineage.[3]

The receptor was discovered in 1987.[4]

Structure

The molecular size is 130 kDa. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants.

Clinical significance

A soluble form of the receptor exists in plasma, commonly denoted sCD163. It is generated by ectodomain shedding of the membrane bound receptor. sCD163 is upregulated in a large range of inflammatory diseases including liver cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher's disease, sepsis, HIV infection, rheumatoid arthritis and Hodgkin Lymphoma.[5][6]

Interactions

CD163 has been shown to interact with CSNK2B.[7]

See also

References

  1. ↑ "Entrez Gene: CD163 CD163 molecule".
  2. ↑ CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Schaer DJ, Schaer CA, Buehler PW, Boykins RA, Schoedon G, Alayash AI, Schaffner A. Blood. 2006 Jan 1;107(1):373-80. PMID 16189277
  3. ↑ Lau SK, Chu PG, Weiss LM (2004). "CD163: a specific marker of macrophages in paraffin-embedded tissues.". Am. J. Clin. Path. 122 (5): 794–801. doi:10.1309/QHD6YFN81KQXUUH6. PMID 15491976.
  4. ↑ Onofre G, Kolácková M, Jankovicová K, Krejsek J (2009). "Scavenger receptor CD163 and its biological functions". Acta Medica (Hradec Kralove) 52 (2): 57–61. PMID 19777868.
  5. ↑ Jones K, Vari F, Keane C, Crooks P, Nourse JP, Seymour LA, Gottlieb D, Ritchie D, Gill D, Gandhi MK (February 2013). "Serum CD163 and TARC as disease response biomarkers in classical Hodgkin lymphoma". Clin. Cancer Res. 19 (3): 731–42. doi:10.1158/1078-0432.CCR-12-2693. PMID 23224400.
  6. ↑ Møller HJ (February 2012). "Soluble CD163". Scand. J. Clin. Lab. Invest. 72 (1): 1–13. doi:10.3109/00365513.2011.626868. PMID 22060747.
  7. ↑ Ritter M, Buechler C, Kapinsky M, Schmitz G (April 2001). "Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C". Eur. J. Immunol. 31 (4): 999–1009. doi:10.1002/1521-4141(200104)31:4<999::AID-IMMU999>3.0.CO;2-R. PMID 11298324.

Further reading

  • Graversen JH, Madsen M, Moestrup SK (2002). "CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma.". Int. J. Biochem. Cell Biol. 34 (4): 309–14. doi:10.1016/S1357-2725(01)00144-3. PMID 11854028. 
  • Madsen M, Graversen JH, Moestrup SK (2002). "Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes.". Redox Rep. 6 (6): 386–8. doi:10.1179/135100001101536490. PMID 11865982. 
  • Moestrup SK, Møller HJ (2005). "CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response.". Ann. Med. 36 (5): 347–54. doi:10.1080/07853890410033171. PMID 15478309. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Law SK, Micklem KJ, Shaw JM, Zhang XP, Dong Y, Willis AC, Mason DY (1993). "A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily.". Eur. J. Immunol. 23 (9): 2320–5. doi:10.1002/eji.1830230940. PMID 8370408. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Droste A, Sorg C, Högger P (1999). "Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family.". Biochem. Biophys. Res. Commun. 256 (1): 110–3. doi:10.1006/bbrc.1999.0294. PMID 10066432. 
  • Ritter M, Buechler C, Langmann T, Schmitz G (1999). "Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily.". Biochem. Biophys. Res. Commun. 260 (2): 466–74. doi:10.1006/bbrc.1999.0866. PMID 10403791. 
  • Van den Heuvel MM, Tensen CP, van As JH, Van den Berg TK, Fluitsma DM, Dijkstra CD, Döpp EA, Droste A, Van Gaalen FA, Sorg C, Högger P, Beelen RH (1999). "Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation.". J. Leukoc. Biol. 66 (5): 858–66. PMID 10577520. 
  • Buechler C, Ritter M, Orsó E, Langmann T, Klucken J, Schmitz G (2000). "Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli.". J. Leukoc. Biol. 67 (1): 97–103. PMID 10648003. 
  • Stover CM, Schleypen J, Grønlund J, Speicher MR, Schwaeble WJ, Holmskov U (2001). "Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis.". Cytogenet. Cell Genet. 90 (3-4): 246–7. doi:10.1159/000056781. PMID 11124526. 
  • Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, Moestrup SK (2001). "Identification of the haemoglobin scavenger receptor.". Nature 409 (6817): 198–201. doi:10.1038/35051594. PMID 11196644. 
  • Ritter M, Buechler C, Kapinsky M, Schmitz G (2001). "Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C.". Eur. J. Immunol. 31 (4): 999–1009. doi:10.1002/1521-4141(200104)31:4<999::AID-IMMU999>3.0.CO;2-R. PMID 11298324. 
  • Sulahian TH, Hintz KA, Wardwell K, Guyre PM (2001). "Development of an ELISA to measure soluble CD163 in biological fluids.". J. Immunol. Methods 252 (1-2): 25–31. doi:10.1016/S0022-1759(01)00328-3. PMID 11334962. 
  • Högger P, Sorg C (2001). "Soluble CD163 inhibits phorbol ester-induced lymphocyte proliferation.". Biochem. Biophys. Res. Commun. 288 (4): 841–3. doi:10.1006/bbrc.2001.5845. PMID 11688984. 
  • Fonseca JE, Edwards JC, Blades S, Goulding NJ (2002). "Macrophage subpopulations in rheumatoid synovium: reduced CD163 expression in CD4+ T lymphocyte-rich microenvironments.". Arthritis Rheum. 46 (5): 1210–6. doi:10.1002/art.10207. PMID 12115225. 
  • Frings W, Dreier J, Sorg C (2002). "Only the soluble form of the scavenger receptor CD163 acts inhibitory on phorbol ester-activated T-lymphocytes, whereas membrane-bound protein has no effect.". FEBS Lett. 526 (1-3): 93–6. doi:10.1016/S0014-5793(02)03142-3. PMID 12208511. 
  • Matsushita N, Kashiwagi M, Wait R, Nagayoshi R, Nakamura M, Matsuda T, Hogger P, Guyre PM, Nagase H, Matsuyama T (2002). "Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3.". Clin. Exp. Immunol. 130 (1): 156–61. doi:10.1046/j.1365-2249.2002.01963.x. PMC 1906487. PMID 12296867. 

External links


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