CADPS
| Ca++-dependent secretion activator | |||||||||||||
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PDB rendering based on 1wi1. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CADPS ; CADPS1; CAPS; CAPS1 | ||||||||||||
| External IDs | OMIM: 604667 MGI: 1350922 HomoloGene: 2755 GeneCards: CADPS Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8618 | 27062 | |||||||||||
| Ensembl | ENSG00000163618 | ENSMUSG00000054423 | |||||||||||
| UniProt | Q9ULU8 | Q80TJ1 | |||||||||||
| RefSeq (mRNA) | NM_003716 | NM_001042617 | |||||||||||
| RefSeq (protein) | NP_003707 | NP_001036082 | |||||||||||
| Location (UCSC) |
Chr 3: 62.4 – 62.88 Mb |
Chr 14: 12.37 – 12.82 Mb | |||||||||||
| PubMed search | |||||||||||||
Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.[1][2]
CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.[2]
References
- ↑ Walent JH, Porter BW, Martin TF (Oct 1992). "A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells". Cell 70 (5): 765–75. doi:10.1016/0092-8674(92)90310-9. PMID 1516133.
- 1 2 "Entrez Gene: CADPS Ca2+-dependent secretion activator".
Further reading
- Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Nishizaki T, Walent JH, Kowalchyk JA, Martin TF (1992). "A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C.". J. Biol. Chem. 267 (33): 23972–81. PMID 1429734.
- Ann K, Kowalchyk JA, Loyet KM, Martin TF (1997). "Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis.". J. Biol. Chem. 272 (32): 19637–40. doi:10.1074/jbc.272.32.19637. PMID 9289490.
- Loyet KM, Kowalchyk JA, Chaudhary A; et al. (1998). "Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis.". J. Biol. Chem. 273 (14): 8337–43. doi:10.1074/jbc.273.14.8337. PMID 9525942.
- Berwin B, Floor E, Martin TF (1998). "CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis.". Neuron 21 (1): 137–45. doi:10.1016/S0896-6273(00)80521-8. PMID 9697858.
- Hirosawa M, Nagase T, Ishikawa K; et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
- Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cisternas FA, Vincent JB, Scherer SW, Ray PN (2003). "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family.". Genomics 81 (3): 279–91. doi:10.1016/S0888-7543(02)00040-X. PMID 12659812.
- Speidel D, Varoqueaux F, Enk C; et al. (2004). "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.". J. Biol. Chem. 278 (52): 52802–9. doi:10.1074/jbc.M304727200. PMID 14530279.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Binda AV, Kabbani N, Levenson R (2005). "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS).". Biochem. Pharmacol. 69 (10): 1451–61. doi:10.1016/j.bcp.2005.02.015. PMID 15857609.
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