Brendan O'Brien
Brendan O'Brien may refer to:
- Brendan O'Brien (cricketer) (born 1942), former Irish cricketer
- Brendan O'Brien (journalist), senior Irish journalist on RTÉ's Prime Time current affairs programme
- Brendan O'Brien (record producer)(born 1960), record producer, mixer, engineer, and musician
- Brendan O'Brien (voice actor) (born 1962), actor and voice of many Crash Bandicoot characters
- Brendan O'Brien (bishop) (born 1943), Roman Catholic archbishop of Kingston, Ontario, Canada
- Brendan O'Brien, former Treasurer of the Law Society of Upper Canada
- Brendan O'Brien, singer who performed with the Irish showband, The Dixies
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