Blaise ketone synthesis

The Blaise ketone synthesis (named after Edmond E. Blaise) is the chemical reaction of acid chlorides with organozinc compounds to give ketones.

The reaction also works with organocuprates.

Reviews have been written.

Variations

Blaise-Maire reaction

The Blaise-Maire reaction is the Blaise ketone synthesis using β-hydroxy acid chlorides to give β-hydroxyketones, which are converted into α,β-unsaturated ketones using sulfuric acid.

See also

References

  1. ^ Blaise, E. E.; Koehler, A. (1910). Bull. Soc. Chim. 7: 215.  Missing or empty |title= (help)
  2. ^ Blaise, E. E. (1911). Bull. Soc. Chim. 9: 1.  Missing or empty |title= (help)
  3. ^ Posner, G. H.; Whitten, C. E. (1976). "Secondary and Tertiary Alkyl Ketones from Carboxylic Acid Chlorides and Lithium Phenylthio(Alkyl)Cuprate Reagents: tert-Butyl Phenyl Ketone". Org. Synth. 55: 122. ; Coll. Vol. 6, p. 248 
  4. ^ Fujisawa, T.; Sato, T. (1988). "Ketones from Carboxylic Acids and Grignard Reagents: Methyl 6-Oxodecanoate". Org. Synth. 66: 116. ; Coll. Vol. 8, p. 441 
  5. ^ Cason, J. (1947). "The Use of Organocadmium Reagents for the Preparation of Ketones". Chem. Rev. 40 (1): 17. doi:10.1021/cr60125a002. PMID 20287882. 
  6. ^ Shirley, D. A. (1954). "The Synthesis of Ketones from Acid Halides and Organometallic Compounds of Magnesium, Zinc, and Cadmium". Org. React. 8: 29. doi:10.1002/0471264180.or008.02. ISBN 0471264180. 
  7. ^ Blaise, E. E.; Maire, M. (1907). Compt. Rend. 145: 73.  Missing or empty |title= (help)


This article is issued from Wikipedia - version of the Monday, January 04, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.