beta-Naphthoflavone

beta-Naphthoflavone

Names
IUPAC name 3-phenyl-1H-benzo[f]chromen-1-one
Other names 5,6-Benzoflavone, BNF
Identifiers
CAS Number	6051-87-2 Y
ChEBI	CHEBI:77013 N
ChEMBL	ChEMBL26260 Y
ChemSpider	2271 Y
DrugBank	DB06732 Y
Jmol interactive 3D	Image
PubChem	2361
InChI InChI=1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H Y Key: OUGIDAPQYNCXRA-UHFFFAOYSA-N Y InChI=1/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H Key: OUGIDAPQYNCXRA-UHFFFAOYAM
SMILES O=C\1c3c(O/C(=C/1)c2ccccc2)ccc4c3cccc4
Properties
Chemical formula	C19H12O2
Molar mass	272.30 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

beta-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and as such is an inducer of such detoxification enzymes as cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs).^[1] β-Naphthoflavone is a putative chemopreventive agent.^[2]

See also

• alpha-Naphthoflavone
• Aryl hydrocarbon receptor

References

1. ↑ Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L (2007). "Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture". Planta Med 73 (8): 742–7. doi:10.1055/s-2007-981548. PMID 17599282. 
2. ↑ Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S (2005). "Modulation of multigene expression and proteome profiles by chemopreventive agents". Mutat Res 11 (591(1–2)): 212–23. doi:10.1016/j.mrfmmm.2005.03.032. PMID 16083920.