BCL11B
B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.[1][2][3]
Function
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined, but it could also be involved in some malignancies. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.[3]
Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly.[4]
Interactions
BCL11B has been shown to interact with COUP-TFI.[5]
References
- ↑ Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJ (Nov 2001). "The BCL11 gene family: involvement of BCL11A in lymphoid malignancies". Blood 98 (12): 3413–20. doi:10.1182/blood.V98.12.3413. PMID 11719382.
- ↑ Topark-Ngarm A, Golonzhka O, Peterson VJ, Barrett B, Martinez B, Crofoot K, Filtz TM, Leid M (Oct 2006). "CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene". J. Biol. Chem. 281 (43): 32272–83. doi:10.1074/jbc.M602776200. PMC 2547407. PMID 16950772.
- 1 2 "Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)".
- ↑ Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M (March 2009). "Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (11): 4278–83. doi:10.1073/pnas.0900568106. PMC 2657370. PMID 19251658. Lay summary – BBC News.
- ↑ Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
Further reading
- Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
- Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M (2002). "COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein". Biochem. J. 368 (Pt 2): 555–63. doi:10.1042/BJ20020496. PMC 1223006. PMID 12196208.
- Wakabayashi Y, Inoue J, Takahashi Y, Matsuki A, Kosugi-Okano H, Shinbo T, Mishima Y, Niwa O, Kominami R (2003). "Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas". Biochem. Biophys. Res. Commun. 301 (2): 598–603. doi:10.1016/S0006-291X(02)03069-3. PMID 12565905.
- Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D, Leid M, Schaeffer E (2003). "Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells". J. Virol. 77 (9): 5415–27. doi:10.1128/JVI.77.9.5415-5427.2003. PMC 153947. PMID 12692243.
- Senawong T, Peterson VJ, Avram D, Shepherd DM, Frye RA, Minucci S, Leid M (2003). "Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression". J. Biol. Chem. 278 (44): 43041–50. doi:10.1074/jbc.M307477200. PMC 2819354. PMID 12930829.
- Bezrookove V, van Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge R, Beverstock GC, Rosenberg C (2004). "A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene". Cancer Genet. Cytogenet. 149 (1): 72–6. doi:10.1016/S0165-4608(03)00302-9. PMID 15104287.
- MacLeod RA, Nagel S, Drexler HG (2004). "BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia". Cancer Genet. Cytogenet. 153 (1): 88–9. doi:10.1016/j.cancergencyto.2004.02.020. PMID 15325104.
- Przybylski GK, Dik WA, Wanzeck J, Grabarczyk P, Majunke S, Martin-Subero JI, Siebert R, Dölken G, Ludwig WD, Verhaaf B, van Dongen JJ, Schmidt CA, Langerak AW (2005). "Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL". Leukemia 19 (2): 201–8. doi:10.1038/sj.leu.2403619. PMID 15668700.
- Cismasiu VB, Adamo K, Gecewicz J, Duque J, Lin Q, Avram D (2005). "BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter". Oncogene 24 (45): 6753–64. doi:10.1038/sj.onc.1208904. PMID 16091750.
- Marban C, Suzanne S, Dequiedt F, de Walque S, Redel L, Van Lint C, Aunis D, Rohr O (2007). "Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing". EMBO J. 26 (2): 412–23. doi:10.1038/sj.emboj.7601516. PMC 1783449. PMID 17245431.
- Nagel S, Scherr M, Kel A, Hornischer K, Crawford GE, Kaufmann M, Meyer C, Drexler HG, MacLeod RA (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1". Cancer Res. 67 (4): 1461–71. doi:10.1158/0008-5472.CAN-06-2615. PMID 17308084.
- Kamimura K, Mishima Y, Obata M, Endo T, Aoyagi Y, Kominami R (2007). "Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages". Oncogene 26 (40): 5840–50. doi:10.1038/sj.onc.1210388. PMID 17369851.
External links
- BCL11B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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