Auxilin
| DnaJ (Hsp40) homolog, subfamily C, member 6 | |||||||||||||
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PDB rendering based on 1n4c. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | DNAJC6 ; DJC6; PARK19 | ||||||||||||
| External IDs | OMIM: 608375 MGI: 1919935 HomoloGene: 8865 GeneCards: DNAJC6 Gene | ||||||||||||
| EC number | 3.1.3.48 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9829 | 72685 | |||||||||||
| Ensembl | ENSG00000116675 | ENSMUSG00000028528 | |||||||||||
| UniProt | O75061 | Q80TZ3 | |||||||||||
| RefSeq (mRNA) | NM_001256864 | NM_001164583 | |||||||||||
| RefSeq (protein) | NP_001243793 | NP_001158055 | |||||||||||
| Location (UCSC) |
Chr 1: 65.25 – 65.42 Mb |
Chr 4: 101.5 – 101.64 Mb | |||||||||||
| PubMed search | |||||||||||||
Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.[1][2][3]
Function
DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).[3]
Structure
The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.[4]
References
- ↑ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Oct 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
- ↑ Ohtsuka K, Hata M (Apr 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:MHDHCO>2.0.CO;2. PMC 312896. PMID 11147971.
- 1 2 "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6".
- ↑ Haynie DT, Xue B (Feb 2015). "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science 24: 874–82. doi:10.1002/pro.2664. PMID 25694109.
Further reading
- Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Scheele U, Alves J, Frank R, Duwel M, Kalthoff C, Ungewickell E (Jul 2003). "Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin". The Journal of Biological Chemistry 278 (28): 25357–68. doi:10.1074/jbc.M303738200. PMID 12732633.
- Scheele U, Kalthoff C, Ungewickell E (Sep 2001). "Multiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex". The Journal of Biological Chemistry 276 (39): 36131–8. doi:10.1074/jbc.M106511200. PMID 11470803.
- Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
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