Astragalus propinquus

Astragalus propinquus
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
(unranked): Rosids
Order: Fabales
Family: Fabaceae
Genus: Astragalus
Species: A. propinquus
Binomial name
Astragalus propinquus
Schischkin[1]
Synonyms
  • "Astragalus membranaceus (Fisch.) Bunge
  • Astragalus membranaceus (Fisch.) Bunge var. mongholicus (Bunge)P.K.Hsiao
  • Astragalus propinquus Schischkin var. glabra Vydr.
  • Phaca membranacea Fisch."[1]

Astragalus propinquus (syn. Astragalus membranaceus[2] also known as huáng qí (Chinese: 黄芪), běi qí (Chinese: 北芪) or huáng huā huáng qí (Chinese: 黄花黄耆),[3] is a flowering plant in the family Fabaceae. It is one of the 50 fundamental herbs used in traditional Chinese medicine.[4] It is a perennial plant and it is not listed as being threatened.[1]

Use

Herbalism

A. propinquus is used in traditional Chinese medicine for healing and for diabetes.[5]

Related species

The natural gum tragacanth, which is used in pharmaceuticals and textiles, is obtained from Astragalus tragacanthus.[6]

Medical

A. propinquus is an component in Lectranal, a food supplement used in treatment of seasonal allergic rhinitis.[7][8]

Chemistry

An extract of A. propinquus called TA-65 may activate telomerase, extending the lengths of the shortest telomeres which protect the terminal DNA at the ends of all chromosomes.[9] It contains the saponin cycloastragenol. Constituents of the roots (Radix Astragali) include polysaccharides, triterpenoids (astragalosides)[10] as well as isoflavones (including kumatakenin, calycosin and formononetin) along with their glycosides and malonates.[11]

Toxicology

While several other species of Astragalus are known to cause severe poisonings in livestock due to indolizine alkaloids, aliphatic nitro compounds, and accumulated selenium,[12] none of these constituents have been detected in the medicinal species Astragalus membranaceus used in dietary supplements and TCM preparations.[13]

Compendial status

A. propinquus is listed in the following official Pharmacopeia:

See also

Notes and references

  1. 1 2 3 "Astragalus propinquus Schischkin". LegumeWeb. International Legume Database & Information Service. 2005-11-01. Retrieved 2012-02-27.
  2. ↑ http://www.ildis.org/LegumeWeb?version~10.01&LegumeWeb&tno~16104&genus~Astragalus&species~membranaceus
  3. ↑ Joe Hing Kwok Chu. "Huang qi". Complementary and Alternative Healing University. Retrieved 2012-02-27.
  4. ↑ "Astragalus membranaceus - Moench.". Plants for a Future.
  5. ↑ Block, Keith I.; Mead, Mark N. (1 September 2003). "Immune System Effects of Echinacea, Ginseng, and Astragalus: A Review". Integrative Cancer Therapies 2 (3): 247–267. doi:10.1177/1534735403256419.
  6. ↑ Gentry, H. S.; Mittleman, M.; McCrohan, P. R. (1990). "Introduction of Chia and Gum Tragacanth in the U.S.". Purdue University Crop Index. Purdue University. Retrieved 2012-02-26.
  7. ↑ Matkovic Z, Zivkovic V, Korica M, Plavec D, Pecanic S, Tudoric N. (2010). "Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis".
  8. ↑ Guo, Ruoling; Pittler, Max H.; Ernst, Edzard (December 2007). "Herbal medicines for the treatment of allergic rhinitis: a systematic review". Annals of Allergy, Asthma & Immunology 99 (6): 483–495. doi:10.1016/S1081-1206(10)60375-4. PMID 18219828.
  9. ↑ Harley, C. B.; Liu, W.; Blasco, M.; Vera, E.; Andrews, W. H.; Briggs, L. A.; Raffaele, J. M. (2011). "A Natural Product Telomerase Activator As Part of a Health Maintenance Program". Rejuvenation Research 14 (1): 45–56. doi:10.1089/rej.2010.1085. PMC 3045570. PMID 20822369.
  10. ↑ Xu, Q.; Ma, X.; Liang, X. (2007). "Determination of Astragalosides in the Roots of Astragalus spp. Using Liquid Chromatography Tandem Atmospheric Pressure Chemical Ionization Mass Spectrometry". Phytochemical Analysis 18 (5): 419–427. doi:10.1002/pca.997. PMID 17624885.
  11. ↑ Lin, L. Z.; He, X. G.; Lindenmaier, M.; Nolan, G.; Yang, J.; Cleary, M.; Qiu, S. X.; Cordell, G. A. (2000). "Liquid Chromatography-Electrospray Ionization Mass Spectrometry Study of the Flavonoids of the Roots of Astragalus mongholicus and A. membranaceus". Journal of Chromatography A 876 (1–2): 87–95. doi:10.1016/S0021-9673(00)00149-7. PMID 10823504.
  12. ↑ "A review of the pharmacology and toxicology of Astragalus". Phytotherapy Research.
  13. ↑ "Astragalus". WebMD.
  14. ↑ Japanese Pharmacopoeia (PDF) (15th ed.).

External links

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