Assisted zona hatching

Assisted zona hatching (AZH) is a procedure of assisted reproductive technology in which a small hole is made in the zona pellucida, using a micromanipulator, thereby facilitating for zona hatching to occur.^[1]^[1] Zona hatching is where the blastocyst gets rid of the surrounding zona pellucida to be able to implant in the uterus.

Efficacy

A systematic review and meta-analysis came to the result that assisted zona hatching is related to increased rates of clinical pregnancy and multiple pregnancy in women with previous repeated failure or frozen-thawed embryos.^[2] However, it is unlikely to increase clinical pregnancy rates when performed in fresh embryos transferred to unselected women, to those without poor prognosis or to women of advanced maternal age.^[2] Also, overall, there no evidence of a significant difference in live birth rate following assisted hatching compared with no assisted hatching.^[3]

References

1 2 IVF-infertility.com
1 2 Martins, W. P.; Rocha, I. A.; Ferriani, R. A.; Nastri, C. O. (2011). "Assisted hatching of human embryos: A systematic review and meta-analysis of randomized controlled trials". Human Reproduction Update. doi:10.1093/humupd/dmr012.
↑ Farquhar, C.; Rishworth, J. R.; Brown, J.; Nelen, W. L. M.; Marjoribanks, J. (2013). Brown, Julie, ed. "Assisted reproductive technology: an overview of Cochrane Reviews". The Cochrane Library 8: CD010537. doi:10.1002/14651858.CD010537.pub2. PMID 23970457.

Assisted reproductive technology

Infertility	Female Male Fertility clinic Fertility testing Fertility tourism

Fertility medication	Estrogen antagonists aromatase inhibitor clomifene FSH GnRH agonists Gonadotropins menotropins hCG

In vitro fertilisation (IVF) and expansions	Assisted zona hatching Autologous endometrial coculture Cytoplasmic transfer Embryo transfer Gestational carrier In vitro maturation Intracytoplasmic sperm injection Oocyte selection Ovarian hyperstimulation Preimplantation genetic diagnosis Snowflake children Transvaginal ovum retrieval Zygote intrafallopian transfer

Other methods	Artificial insemination sperm donation Cryopreservation embryos oocyte ovarian tissue semen Gamete intrafallopian transfer Reproductive surgery vasectomy reversal Semen collection Sex selection Surrogacy

Donation	Donor registration Donor Sibling Registry Egg donation Embryo Sperm Sperm bank

Ethics	Accidental incest Religious response to ART Mitochondrial donation

In fiction	See subsection in sperm donation Reproduction and pregnancy in speculative fiction

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