Amnionless

Amnion associated transmembrane protein
Identifiers
Symbols AMN ; PRO1028; amnionless
External IDs OMIM: 605799 MGI: 1934943 HomoloGene: 12804 GeneCards: AMN Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 81693 93835
Ensembl ENSG00000166126 ENSMUSG00000021278
UniProt Q9BXJ7 Q99JB7
RefSeq (mRNA) NM_030943 NM_033603
RefSeq (protein) NP_112205 NP_291081
Location (UCSC) Chr 14:
102.92 – 102.93 Mb
Chr 12:
111.27 – 111.28 Mb
PubMed search

Amnionless is a protein that in humans is encoded by the AMN gene.[1][2]

Function

A complex of amnionless and cubilin forms the cubam receptor.

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.[2]

References

  1. Kalantry S, Manning S, Haub O, Tomihara-Newberger C, Lee HG, Fangman J, Disteche CM, Manova K, Lacy E (Mar 2001). "The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain". Nat Genet 27 (4): 412–6. doi:10.1038/86912. PMID 11279523.
  2. 1 2 "Entrez Gene: AMN amnionless homolog (mouse)".

Further reading

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